Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1372533..1373041 Replicon chromosome
Accession NZ_CP063046
Organism Escherichia coli strain KC-Dl-1

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag IL980_RS06660 Protein ID WP_001534843.1
Coordinates 1372832..1373041 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A0V9L4L3
Locus tag IL980_RS06655 Protein ID WP_000063161.1
Coordinates 1372533..1372835 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL980_RS06640 1369061..1371211 + 2151 WP_001366791.1 pyruvate/proton symporter BtsT -
IL980_RS06645 1371329..1371532 + 204 WP_001534846.1 YbdD/YjiX family protein -
IL980_RS06650 1371543..1372499 + 957 WP_001534845.1 GTPase -
IL980_RS06655 1372533..1372835 - 303 WP_000063161.1 BrnA antitoxin family protein Antitoxin
IL980_RS06660 1372832..1373041 - 210 WP_001534843.1 BrnT family toxin Toxin
IL980_RS06665 1373137..1374303 + 1167 WP_197613138.1 restriction endonuclease -
IL980_RS06670 1374367..1375985 + 1619 Protein_1302 type I restriction-modification system subunit M -
IL980_RS06675 1375975..1377285 + 1311 WP_001534837.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7952.17 Da        Isoelectric Point: 4.9493

>T177540 WP_001534843.1 NZ_CP063046:c1373041-1372832 [Escherichia coli]
MVDYPKRDAISNINAIIVDTFLYIQLGMATMPMEFEWNANKAKSNRVKHGIRFEDAVLVLDDPQRTEPL

Download         Length: 210 bp

>T177540 NZ_CP083530:c1611567-1611460 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11600.10 Da        Isoelectric Point: 9.4646

>AT177540 WP_000063161.1 NZ_CP063046:c1372835-1372533 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKVLANKFDEDIDYSDIPSSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT177540 NZ_CP083530:1611615-1611681 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9L4L3

References