177535

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 127687..128488 Replicon chromosome
Accession NZ_CP063046
Organism Escherichia coli strain KC-Dl-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag IL980_RS00740 Protein ID WP_000854739.1
Coordinates 127687..128067 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag IL980_RS00745 Protein ID WP_001285482.1
Coordinates 128114..128488 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL980_RS00705 123279..123833 - 555 WP_001001921.1 molecular chaperone YcdY -
IL980_RS00710 123857..124594 - 738 WP_000283664.1 zinc-binding phosphatase -
IL980_RS00715 124649..125587 - 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
IL980_RS00725 126073..126900 - 828 WP_001518536.1 DUF4942 domain-containing protein -
IL980_RS00730 126985..127182 - 198 WP_000772027.1 DUF957 domain-containing protein -
IL980_RS00735 127202..127690 - 489 WP_001518535.1 hypothetical protein -
IL980_RS00740 127687..128067 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
IL980_RS00745 128114..128488 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IL980_RS00750 128538..129182 - 645 WP_000086759.1 hypothetical protein -
IL980_RS00755 129201..129422 - 222 WP_000692315.1 DUF987 domain-containing protein -
IL980_RS00760 129485..129961 - 477 WP_001313574.1 RadC family protein -
IL980_RS00765 129977..130450 - 474 WP_001313575.1 antirestriction protein -
IL980_RS00770 130544..130789 - 246 WP_001164966.1 hypothetical protein -
IL980_RS00775 130789..131607 - 819 WP_001560884.1 DUF945 domain-containing protein -
IL980_RS00780 131762..131896 - 135 WP_032144430.1 DUF905 family protein -
IL980_RS00785 131997..132452 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T177535 WP_000854739.1 NZ_CP063046:c128067-127687 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T177535 NZ_CP083514:c75647-75495 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT177535 WP_001285482.1 NZ_CP063046:c128488-128114 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT177535 NZ_CP083514:75697-75759 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References