Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3939652..3940271 Replicon chromosome
Accession NZ_CP063023
Organism Klebsiella pneumoniae strain CriePir45

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GJJ13_RS19165 Protein ID WP_002892050.1
Coordinates 3940053..3940271 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GJJ13_RS19160 Protein ID WP_002892066.1
Coordinates 3939652..3940026 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ13_RS19150 3934804..3935997 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GJJ13_RS19155 3936020..3939166 + 3147 WP_102024722.1 multidrug efflux RND transporter permease subunit AcrB -
GJJ13_RS19160 3939652..3940026 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GJJ13_RS19165 3940053..3940271 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GJJ13_RS19170 3940430..3940996 + 567 WP_002892030.1 maltose O-acetyltransferase -
GJJ13_RS19175 3940968..3941108 - 141 WP_004147370.1 hypothetical protein -
GJJ13_RS19180 3941129..3941599 + 471 WP_002892026.1 YlaC family protein -
GJJ13_RS19185 3941574..3943025 - 1452 WP_151502951.1 PLP-dependent aminotransferase family protein -
GJJ13_RS19190 3943126..3943824 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
GJJ13_RS19195 3943821..3943961 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GJJ13_RS19200 3943961..3944224 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T177531 WP_002892050.1 NZ_CP063023:3940053-3940271 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T177531 NZ_CP083513:c155889-155473 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT177531 WP_002892066.1 NZ_CP063023:3939652-3940026 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT177531 NZ_CP083513:c156116-155886 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References