Detailed information of TA system TA177530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2622796..2624384
• Replicon: chromosome
• Accession: NZ_CP063023
• Organism: Klebsiella pneumoniae strain CriePir45

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GJJ13_RS12805
• Protein ID: WP_153932396.1
• Coordinates: 2622796..2624118 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: GJJ13_RS12810
• Protein ID: WP_002904790.1
• Coordinates: 2624118..2624384 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJJ13_RS12785	2619358..2619606	+	249	WP_002904810.1	hypothetical protein	-
GJJ13_RS12790	2619896..2620114	+	219	WP_002904808.1	ParD-like family protein	-
GJJ13_RS12795	2620095..2620877	+	783	WP_004179825.1	type I methionyl aminopeptidase	-
GJJ13_RS12800	2621487..2622779	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
GJJ13_RS12805	2622796..2624118	-	1323	WP_153932396.1	type II toxin-antitoxin system HipA family toxin	Toxin
GJJ13_RS12810	2624118..2624384	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
GJJ13_RS12815	2624892..2625218	-	327	WP_100127219.1	hydroxyisourate hydrolase	-
GJJ13_RS12820	2625215..2625715	-	501	WP_153932397.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
GJJ13_RS12825	2625693..2627072	-	1380	WP_004184021.1	purine permease	-
GJJ13_RS12830	2627418..2628572	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49141.48 Da
• Isoelectric Point: 7.5366

>T177530 WP_153932396.1 NZ_CP063023:c2624118-2622796 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSLRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T177530 NZ_CP083513:48551-48700 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT177530 WP_002904790.1 NZ_CP063023:c2624384-2624118 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT177530 NZ_CP083513:c48507-48446 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8