Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805731..806388 Replicon chromosome
Accession NZ_CP063023
Organism Klebsiella pneumoniae strain CriePir45

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GJJ13_RS03975 Protein ID WP_002916310.1
Coordinates 805978..806388 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GJJ13_RS03970 Protein ID WP_002916312.1
Coordinates 805731..805997 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ13_RS03945 800887..802320 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
GJJ13_RS03950 802439..803167 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GJJ13_RS03955 803217..803528 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
GJJ13_RS03960 803692..804351 + 660 WP_002916317.1 hemolysin III family protein -
GJJ13_RS03965 804502..805485 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GJJ13_RS03970 805731..805997 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GJJ13_RS03975 805978..806388 + 411 WP_002916310.1 protein YgfX Toxin
GJJ13_RS03980 806395..806916 - 522 WP_004144730.1 flavodoxin FldB -
GJJ13_RS03985 807017..807913 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GJJ13_RS03990 807936..808649 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GJJ13_RS03995 808655..810388 + 1734 WP_151502932.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T177521 WP_002916310.1 NZ_CP063023:805978-806388 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T177521 NZ_CP083512:3471256-3471429 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT177521 WP_002916312.1 NZ_CP063023:805731-805997 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT177521 NZ_CP083512:3470932-3471228 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGCATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References