Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 44787..45430 Replicon plasmid unnamed1
Accession NZ_CP063020
Organism Klebsiella pneumoniae strain CriePir75

Toxin (Protein)


Gene name vagD Uniprot ID A0A7Z7T700
Locus tag GJJ10_RS27370 Protein ID WP_040155119.1
Coordinates 45014..45430 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag GJJ10_RS27365 Protein ID WP_001261276.1
Coordinates 44787..45017 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ10_RS27330 39906..40175 + 270 WP_000339857.1 hypothetical protein -
GJJ10_RS27335 40352..41218 - 867 WP_004118283.1 replication initiation protein -
GJJ10_RS27340 41748..41852 + 105 WP_032409716.1 hypothetical protein -
GJJ10_RS27345 41981..42238 + 258 WP_000764642.1 hypothetical protein -
GJJ10_RS27350 42296..43072 - 777 WP_153945667.1 site-specific integrase -
GJJ10_RS27355 43069..43812 - 744 WP_000129823.1 hypothetical protein -
GJJ10_RS27360 43863..44213 - 351 WP_000493378.1 hypothetical protein -
GJJ10_RS27365 44787..45017 + 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GJJ10_RS27370 45014..45430 + 417 WP_040155119.1 type II toxin-antitoxin system VapC family toxin Toxin
GJJ10_RS27375 45471..46349 - 879 WP_009309916.1 restriction endonuclease -
GJJ10_RS27380 47011..48288 + 1278 Protein_54 HlyD family secretion protein -
GJJ10_RS27385 48278..50386 + 2109 WP_019725134.1 peptidase domain-containing ABC transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaTEM-1B / qnrS1 / sul1 / qacE / dfrA1 / tet(A) / catA1 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IIa / blaCTX-M-15 - 1..79562 79562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15147.60 Da        Isoelectric Point: 7.8915

>T177518 WP_040155119.1 NZ_CP063020:45014-45430 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPESVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIHLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFERVPGLVLEDWVK

Download         Length: 417 bp

>T177518 NZ_CP083512:c1923787-1923380 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGTCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT177518 WP_001261276.1 NZ_CP063020:44787-45017 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT177518 NZ_CP083512:c1924034-1923768 [Escherichia coli]
ATGTACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7T700

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References