Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 4821081..4821772 | Replicon | chromosome |
| Accession | NZ_CP063019 | ||
| Organism | Klebsiella pneumoniae strain CriePir75 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | A0A483YFJ1 |
| Locus tag | GJJ10_RS23895 | Protein ID | WP_025987721.1 |
| Coordinates | 4821081..4821422 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A2A5MHA6 |
| Locus tag | GJJ10_RS23900 | Protein ID | WP_019725272.1 |
| Coordinates | 4821446..4821772 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GJJ10_RS23880 | 4818040..4819275 | - | 1236 | WP_124044824.1 | hypothetical protein | - |
| GJJ10_RS23885 | 4819735..4820046 | - | 312 | WP_073568733.1 | hypothetical protein | - |
| GJJ10_RS23890 | 4820133..4820966 | - | 834 | WP_025987720.1 | DUF4942 domain-containing protein | - |
| GJJ10_RS23895 | 4821081..4821422 | - | 342 | WP_025987721.1 | TA system toxin CbtA family protein | Toxin |
| GJJ10_RS23900 | 4821446..4821772 | - | 327 | WP_019725272.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| GJJ10_RS23905 | 4821786..4822262 | - | 477 | WP_019725273.1 | DNA repair protein RadC | - |
| GJJ10_RS23910 | 4822272..4822718 | - | 447 | WP_025987722.1 | antirestriction protein | - |
| GJJ10_RS23915 | 4822930..4823619 | - | 690 | WP_009309812.1 | hypothetical protein | - |
| GJJ10_RS23920 | 4824184..4825074 | - | 891 | WP_019725276.1 | 50S ribosome-binding GTPase | - |
| GJJ10_RS23925 | 4825157..4826245 | - | 1089 | WP_019725277.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4802799..4845916 | 43117 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12867.90 Da Isoelectric Point: 8.5195
>T177514 WP_025987721.1 NZ_CP063019:c4821422-4821081 [Klebsiella pneumoniae]
MKTLPATIQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR
MKTLPATIQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR
Download Length: 342 bp
>T177514 NZ_CP083512:c73192-73085 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12276.01 Da Isoelectric Point: 6.9560
>AT177514 WP_019725272.1 NZ_CP063019:c4821772-4821446 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR
Download Length: 327 bp
>AT177514 NZ_CP083512:73245-73306 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A483YFJ1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A5MHA6 |