Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4156935..4157554 Replicon chromosome
Accession NZ_CP063019
Organism Klebsiella pneumoniae strain CriePir75

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GJJ10_RS20695 Protein ID WP_002892050.1
Coordinates 4157336..4157554 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GJJ10_RS20690 Protein ID WP_002892066.1
Coordinates 4156935..4157309 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ10_RS20680 4152087..4153280 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GJJ10_RS20685 4153303..4156449 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GJJ10_RS20690 4156935..4157309 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GJJ10_RS20695 4157336..4157554 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GJJ10_RS20700 4157713..4158279 + 567 WP_002892030.1 maltose O-acetyltransferase -
GJJ10_RS20705 4158251..4158391 - 141 WP_004147370.1 hypothetical protein -
GJJ10_RS20710 4158412..4158882 + 471 WP_002892026.1 YlaC family protein -
GJJ10_RS20715 4158857..4160308 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
GJJ10_RS20720 4160409..4161107 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
GJJ10_RS20725 4161104..4161244 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GJJ10_RS20730 4161244..4161507 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T177512 WP_002892050.1 NZ_CP063019:4157336-4157554 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T177512 NZ_CP083504:c69470-69321 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT177512 WP_002892066.1 NZ_CP063019:4156935-4157309 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT177512 NZ_CP083504:69514-69575 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References