Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876981..877638 Replicon chromosome
Accession NZ_CP063019
Organism Klebsiella pneumoniae strain CriePir75

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GJJ10_RS04410 Protein ID WP_002916310.1
Coordinates 877228..877638 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GJJ10_RS04405 Protein ID WP_002916312.1
Coordinates 876981..877247 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ10_RS04380 872137..873570 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
GJJ10_RS04385 873689..874417 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GJJ10_RS04390 874467..874778 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
GJJ10_RS04395 874942..875601 + 660 WP_002916317.1 hemolysin III family protein -
GJJ10_RS04400 875752..876735 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GJJ10_RS04405 876981..877247 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GJJ10_RS04410 877228..877638 + 411 WP_002916310.1 protein YgfX Toxin
GJJ10_RS04415 877645..878166 - 522 WP_002916308.1 flavodoxin FldB -
GJJ10_RS04420 878267..879163 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GJJ10_RS04425 879186..879899 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GJJ10_RS04430 879905..881638 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T177502 WP_002916310.1 NZ_CP063019:877228-877638 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T177502 NZ_CP083503:c3103027-3102920 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT177502 WP_002916312.1 NZ_CP063019:876981-877247 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT177502 NZ_CP083503:3103085-3103139 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References