Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 742569..743344 Replicon chromosome
Accession NZ_CP063019
Organism Klebsiella pneumoniae strain CriePir75

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag GJJ10_RS03690 Protein ID WP_004150910.1
Coordinates 742859..743344 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag GJJ10_RS03685 Protein ID WP_004150912.1
Coordinates 742569..742862 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ10_RS03665 737777..738379 - 603 WP_002916735.1 short chain dehydrogenase -
GJJ10_RS03670 738477..739388 + 912 WP_004188550.1 LysR family transcriptional regulator -
GJJ10_RS03675 739389..740537 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
GJJ10_RS03680 740548..741924 - 1377 WP_004217775.1 cystathionine beta-synthase -
GJJ10_RS03685 742569..742862 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
GJJ10_RS03690 742859..743344 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
GJJ10_RS03695 744048..744641 + 594 WP_004188553.1 hypothetical protein -
GJJ10_RS03700 744738..744954 + 217 Protein_725 transposase -
GJJ10_RS03705 745560..746432 + 873 WP_004188557.1 ParA family protein -
GJJ10_RS03710 746432..746815 + 384 WP_004150906.1 hypothetical protein -
GJJ10_RS03715 746808..748175 + 1368 WP_004150905.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T177501 WP_004150910.1 NZ_CP063019:742859-743344 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T177501 NZ_CP083503:c3102543-3102436 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT177501 WP_004150912.1 NZ_CP063019:742569-742862 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT177501 NZ_CP083503:3102591-3102657 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References