Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4853131..4853647 Replicon chromosome
Accession NZ_CP063011
Organism Klebsiella pneumoniae strain CriePir116

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag GJI97_RS23870 Protein ID WP_002886902.1
Coordinates 4853131..4853415 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GJI97_RS23875 Protein ID WP_002886901.1
Coordinates 4853405..4853647 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJI97_RS23845 4848615..4848923 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
GJI97_RS23850 4849008..4849181 + 174 WP_002886906.1 hypothetical protein -
GJI97_RS23855 4849184..4849927 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GJI97_RS23860 4850284..4852422 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
GJI97_RS23865 4852663..4853127 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GJI97_RS23870 4853131..4853415 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJI97_RS23875 4853405..4853647 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GJI97_RS23880 4853725..4855635 - 1911 WP_004152270.1 BglG family transcription antiterminator -
GJI97_RS23885 4855658..4856812 - 1155 WP_002886900.1 lactonase family protein -
GJI97_RS23890 4856878..4857618 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T177496 WP_002886902.1 NZ_CP063011:c4853415-4853131 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T177496 NZ_CP083503:c2390163-2389756 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT177496 WP_002886901.1 NZ_CP063011:c4853647-4853405 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT177496 NZ_CP083503:c2390410-2390144 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References