Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4177895..4178514 Replicon chromosome
Accession NZ_CP063008
Organism Klebsiella pneumoniae strain CriePir120

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GJJ08_RS20710 Protein ID WP_002892050.1
Coordinates 4178296..4178514 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GJJ08_RS20705 Protein ID WP_002892066.1
Coordinates 4177895..4178269 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ08_RS20695 4173047..4174240 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GJJ08_RS20700 4174263..4177409 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GJJ08_RS20705 4177895..4178269 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GJJ08_RS20710 4178296..4178514 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GJJ08_RS20715 4178673..4179239 + 567 WP_002892030.1 maltose O-acetyltransferase -
GJJ08_RS20720 4179211..4179351 - 141 WP_004147370.1 hypothetical protein -
GJJ08_RS20725 4179372..4179842 + 471 WP_002892026.1 YlaC family protein -
GJJ08_RS20730 4179817..4181268 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
GJJ08_RS20735 4181369..4182067 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
GJJ08_RS20740 4182064..4182204 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GJJ08_RS20745 4182204..4182467 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T177476 WP_002892050.1 NZ_CP063008:4178296-4178514 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T177476 NZ_CP083498:39953-40102 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT177476 WP_002892066.1 NZ_CP063008:4177895-4178269 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT177476 NZ_CP083498:c39909-39848 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References