Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4742848..4743364 Replicon chromosome
Accession NZ_CP063003
Organism Klebsiella pneumoniae strain CriePir154

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag GJI94_RS23375 Protein ID WP_002886902.1
Coordinates 4742848..4743132 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GJI94_RS23380 Protein ID WP_002886901.1
Coordinates 4743122..4743364 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJI94_RS23350 4738332..4738640 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
GJI94_RS23355 4738725..4738898 + 174 WP_002886906.1 hypothetical protein -
GJI94_RS23360 4738901..4739644 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GJI94_RS23365 4740001..4742139 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
GJI94_RS23370 4742380..4742844 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GJI94_RS23375 4742848..4743132 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJI94_RS23380 4743122..4743364 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GJI94_RS23385 4743442..4745352 - 1911 WP_004152270.1 BglG family transcription antiterminator -
GJI94_RS23390 4745375..4746529 - 1155 WP_002886900.1 lactonase family protein -
GJI94_RS23395 4746595..4747335 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T177459 WP_002886902.1 NZ_CP063003:c4743132-4742848 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T177459 NZ_CP083497:963527-963634 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT177459 WP_002886901.1 NZ_CP063003:c4743364-4743122 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT177459 NZ_CP083497:c963477-963414 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References