Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4704655..4705171 Replicon chromosome
Accession NZ_CP062997
Organism Klebsiella pneumoniae strain CriePir197

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag GJJ12_RS23230 Protein ID WP_009309309.1
Coordinates 4704655..4704939 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GJJ12_RS23235 Protein ID WP_002886901.1
Coordinates 4704929..4705171 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ12_RS23205 4700050..4700358 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
GJJ12_RS23210 4700443..4700616 + 174 WP_032408826.1 hypothetical protein -
GJJ12_RS23215 4700619..4701362 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GJJ12_RS23220 4701719..4703857 + 2139 WP_009309308.1 anaerobic ribonucleoside-triphosphate reductase -
GJJ12_RS23225 4704187..4704651 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GJJ12_RS23230 4704655..4704939 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJJ12_RS23235 4704929..4705171 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GJJ12_RS23240 4705249..4707159 - 1911 WP_009309311.1 BglG family transcription antiterminator -
GJJ12_RS23245 4707182..4708336 - 1155 WP_009309312.1 lactonase family protein -
GJJ12_RS23250 4708403..4709143 - 741 WP_009309313.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T177438 WP_009309309.1 NZ_CP062997:c4704939-4704655 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T177438 NZ_CP083492:2532239-2532517 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT177438 WP_002886901.1 NZ_CP062997:c4705171-4704929 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT177438 NZ_CP083492:2531976-2532236 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTTACTGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References