Detailed information of TA system TA177425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1814798..1816386
• Replicon: chromosome
• Accession: NZ_CP062997
• Organism: Klebsiella pneumoniae strain CriePir197

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GJJ12_RS08855
• Protein ID: WP_048980818.1
• Coordinates: 1815064..1816386 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: GJJ12_RS08850
• Protein ID: WP_002904790.1
• Coordinates: 1814798..1815064 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJJ12_RS08825	1809828..1810751	+	924	WP_048980813.1	LysR family hpxDE operon transcriptional regulator HpxR	-
GJJ12_RS08830	1810732..1811886	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
GJJ12_RS08835	1812232..1813611	+	1380	WP_004184021.1	purine permease	-
GJJ12_RS08840	1813589..1814089	+	501	WP_048980815.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
GJJ12_RS08845	1814086..1814412	+	327	WP_004184023.1	hydroxyisourate hydrolase	-
GJJ12_RS08850	1814798..1815064	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
GJJ12_RS08855	1815064..1816386	+	1323	WP_048980818.1	type II toxin-antitoxin system HipA family toxin	Toxin
GJJ12_RS08860	1816403..1817695	-	1293	WP_015958402.1	glycoside hydrolase family 10 protein	-
GJJ12_RS08865	1817837..1818841	-	1005	WP_009308876.1	type 1 fimbrial protein	-
GJJ12_RS08870	1818829..1821330	-	2502	WP_061891829.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49125.44 Da
• Isoelectric Point: 7.5367

>T177425 WP_048980818.1 NZ_CP062997:1815064-1816386 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAVTENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T177425 NZ_CP083486:c8044-7664 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT177425 WP_002904790.1 NZ_CP062997:1814798-1815064 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT177425 NZ_CP083486:c8265-8044 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8