Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812004..812661 Replicon chromosome
Accession NZ_CP062997
Organism Klebsiella pneumoniae strain CriePir197

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GJJ12_RS04050 Protein ID WP_002916310.1
Coordinates 812251..812661 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GJJ12_RS04045 Protein ID WP_002916312.1
Coordinates 812004..812270 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ12_RS04020 807160..808593 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
GJJ12_RS04025 808712..809440 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GJJ12_RS04030 809490..809801 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GJJ12_RS04035 809965..810624 + 660 WP_002916317.1 hemolysin III family protein -
GJJ12_RS04040 810775..811758 - 984 WP_009308615.1 tRNA-modifying protein YgfZ -
GJJ12_RS04045 812004..812270 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GJJ12_RS04050 812251..812661 + 411 WP_002916310.1 protein YgfX Toxin
GJJ12_RS04055 812668..813189 - 522 WP_004144730.1 flavodoxin FldB -
GJJ12_RS04060 813290..814186 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GJJ12_RS04065 814209..814922 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GJJ12_RS04070 814928..816661 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T177424 WP_002916310.1 NZ_CP062997:812251-812661 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T177424 NZ_CP083484:218176-218481 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT177424 WP_002916312.1 NZ_CP062997:812004-812270 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT177424 NZ_CP083484:217956-218174 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References