Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795170..795827 Replicon chromosome
Accession NZ_CP062986
Organism Klebsiella pneumoniae strain CriePir26

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GJJ26_RS03960 Protein ID WP_002916310.1
Coordinates 795417..795827 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GJJ26_RS03955 Protein ID WP_002916312.1
Coordinates 795170..795436 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ26_RS03930 (GJJ26_003930) 790378..791811 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
GJJ26_RS03935 (GJJ26_003935) 791930..792658 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GJJ26_RS03940 (GJJ26_003940) 792708..793019 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GJJ26_RS03945 (GJJ26_003945) 793183..793842 + 660 WP_002916317.1 hemolysin III family protein -
GJJ26_RS03950 (GJJ26_003950) 793941..794924 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GJJ26_RS03955 (GJJ26_003955) 795170..795436 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GJJ26_RS03960 (GJJ26_003960) 795417..795827 + 411 WP_002916310.1 protein YgfX Toxin
GJJ26_RS03965 (GJJ26_003965) 795834..796355 - 522 WP_002916308.1 flavodoxin FldB -
GJJ26_RS03970 (GJJ26_003970) 796456..797352 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GJJ26_RS03975 (GJJ26_003975) 797375..798088 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GJJ26_RS03980 (GJJ26_003980) 798094..799827 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T177403 WP_002916310.1 NZ_CP062986:795417-795827 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T177403 NZ_CP083481:1518241-1518627 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT177403 WP_002916312.1 NZ_CP062986:795170-795436 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT177403 NZ_CP083481:1518617-1518946 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References