Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 324326..324912 Replicon chromosome
Accession NZ_CP062986
Organism Klebsiella pneumoniae strain CriePir26

Toxin (Protein)


Gene name doc Uniprot ID A0A9J6Y968
Locus tag GJJ26_RS01510 Protein ID WP_025367836.1
Coordinates 324544..324912 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag GJJ26_RS01505 Protein ID WP_004174006.1
Coordinates 324326..324547 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ26_RS01485 (GJJ26_001485) 320483..321409 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
GJJ26_RS01490 (GJJ26_001490) 321406..322683 + 1278 WP_004188292.1 branched chain amino acid ABC transporter permease LivM -
GJJ26_RS01495 (GJJ26_001495) 322680..323447 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
GJJ26_RS01500 (GJJ26_001500) 323449..324162 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
GJJ26_RS01505 (GJJ26_001505) 324326..324547 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GJJ26_RS01510 (GJJ26_001510) 324544..324912 + 369 WP_025367836.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GJJ26_RS01515 (GJJ26_001515) 325185..326501 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
GJJ26_RS01520 (GJJ26_001520) 326608..327495 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
GJJ26_RS01525 (GJJ26_001525) 327492..328337 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
GJJ26_RS01530 (GJJ26_001530) 328339..329409 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 320483..330146 9663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13449.86 Da        Isoelectric Point: 7.2790

>T177401 WP_025367836.1 NZ_CP062986:324544-324912 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIECEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLLG

Download         Length: 369 bp

>T177401 NZ_CP083481:1051446-1051553 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT177401 WP_004174006.1 NZ_CP062986:324326-324547 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT177401 NZ_CP083481:c1051393-1051332 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References