Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2384002..2384630 Replicon chromosome
Accession NZ_CP062976
Organism Neisseria sp. ZJ785

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H4O27_RS11590 Protein ID WP_165007266.1
Coordinates 2384229..2384630 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H4O27_RS11585 Protein ID WP_165007045.1
Coordinates 2384002..2384226 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4O27_RS11565 2379381..2380010 - 630 WP_165007055.1 DUF533 domain-containing protein -
H4O27_RS11570 2380229..2381659 + 1431 WP_165007052.1 basic amino acid/polyamine antiporter -
H4O27_RS11575 2381656..2381823 - 168 WP_165007050.1 hypothetical protein -
H4O27_RS11580 2381990..2383852 - 1863 WP_165007048.1 RNB domain-containing ribonuclease -
H4O27_RS11585 2384002..2384226 + 225 WP_165007045.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H4O27_RS11590 2384229..2384630 + 402 WP_165007266.1 tRNA(fMet)-specific endonuclease VapC Toxin
H4O27_RS11595 2385063..2385797 - 735 WP_165007264.1 tRNA pseudouridine(65) synthase TruC -
H4O27_RS11600 2385937..2386668 + 732 WP_165007042.1 TIGR00730 family Rossman fold protein -
H4O27_RS11605 2387113..2387469 + 357 WP_165007039.1 NADH-quinone oxidoreductase subunit A -
H4O27_RS11610 2387460..2387939 + 480 WP_165007037.1 NADH-quinone oxidoreductase subunit B -
H4O27_RS11615 2387944..2388537 + 594 WP_165007034.1 NADH-quinone oxidoreductase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-35)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14692.82 Da        Isoelectric Point: 6.7511

>T177369 WP_165007266.1 NZ_CP062976:2384229-2384630 [Neisseria sp. ZJ785]
ILRYMLDTNICIYTIKNNPAAVREKFGRHQHHLCISSIVLSELLYGAEKSANPEKSLAIVEGLAARLEVQDFDDTAAAHA
ADIRAALAKKGTPIGHYDVLIAGHARSRGLVLVSNNMREFERVDGLLLENWAE

Download         Length: 402 bp

>T177369 NZ_CP083474:195512-195784 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8469.68 Da        Isoelectric Point: 4.6544

>AT177369 WP_165007045.1 NZ_CP062976:2384002-2384226 [Neisseria sp. ZJ785]
MMQATIFKSNQTQALRLPKAVAFPDNVKKVDVVVLGKTRLLTPSENLWDDWFALLDAADFPDREPTFQAERESF

Download         Length: 225 bp

>AT177369 NZ_CP083474:195249-195512 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References