Detailed information of TA system TA177368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1276577..1277063
• Replicon: chromosome
• Accession: NZ_CP062976
• Organism: Neisseria sp. ZJ785

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: H4O27_RS06105
• Protein ID: WP_165007707.1
• Coordinates: 1276785..1277063 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: H4O27_RS06100
• Protein ID: WP_165007704.1
• Coordinates: 1276577..1276801 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4O27_RS06075	1272594..1272902	-	309	WP_165007692.1	hypothetical protein	-
H4O27_RS06080	1273656..1273841	-	186	WP_165007695.1	hypothetical protein	-
H4O27_RS06085	1273834..1275875	-	2042	Protein_1165	type IV conjugative transfer system coupling protein TraD	-
H4O27_RS06090	1275878..1276075	-	198	WP_165007698.1	hypothetical protein	-
H4O27_RS06095	1276056..1276451	+	396	WP_165007701.1	helix-turn-helix domain-containing protein	-
H4O27_RS06100	1276577..1276801	+	225	WP_165007704.1	TraY domain-containing protein	Antitoxin
H4O27_RS06105	1276785..1277063	+	279	WP_165007707.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H4O27_RS06110	1277085..1277783	-	699	WP_165007844.1	transglycosylase SLT domain-containing protein	-
H4O27_RS06115	1277973..1278194	+	222	WP_165007710.1	hypothetical protein	-
H4O27_RS06120	1278231..1281533	-	3303	WP_165007713.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (3-49)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10749.52 Da
• Isoelectric Point: 10.5054

>T177368 WP_165007707.1 NZ_CP062976:1276785-1277063 [Neisseria sp. ZJ785]
MAWKVELHRTAEKELAKLDKQVAVRILKFLHERVAASENPRQIGEALKGSALGEYWKYRVGDYRIITEIKDNVLTVLVLK
VGNRREIYRSRN

Nucleotide

• Length: 279 bp

>T177368 NZ_CP083474:c165322-165065 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8404.60 Da
• Isoelectric Point: 4.6386

>AT177368 WP_165007704.1 NZ_CP062976:1276577-1276801 [Neisseria sp. ZJ785]
MIAVRLPEDIEARLAELAAKTGRTKTFYVREAVLSHLEDLEDLYLAEQRSIEIQAGRSQPVSLEEVMKRYGLEG

Nucleotide

• Length: 225 bp

>AT177368 NZ_CP083474:c165584-165315 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA