Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 1036129..1036684 Replicon chromosome
Accession NZ_CP062952
Organism Bifidobacterium longum subsp. infantis strain JCM 11660

Toxin (Protein)


Gene name mazF Uniprot ID A0A7L9TZR4
Locus tag BL1660_RS04700 Protein ID WP_071474571.1
Coordinates 1036361..1036684 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S2ZDC4
Locus tag BL1660_RS04695 Protein ID WP_003829112.1
Coordinates 1036129..1036374 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL1660_RS04675 1031971..1032633 + 663 WP_019728044.1 TetR/AcrR family transcriptional regulator -
BL1660_RS04680 1032788..1034059 + 1272 WP_117717419.1 MFS transporter -
BL1660_RS04685 1034243..1034434 - 192 WP_025341701.1 XRE family transcriptional regulator -
BL1660_RS04690 1034699..1035955 - 1257 WP_003829116.1 HipA domain-containing protein -
BL1660_RS04695 1036129..1036374 + 246 WP_003829112.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BL1660_RS04700 1036361..1036684 + 324 WP_071474571.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BL1660_RS04705 1036901..1037515 - 615 WP_003833461.1 cupin domain-containing protein -
BL1660_RS04710 1037610..1038479 - 870 WP_003829104.1 class I SAM-dependent methyltransferase -
BL1660_RS04715 1038717..1039082 + 366 WP_193641223.1 YccF domain-containing protein -
BL1660_RS04720 1039627..1040892 + 1266 WP_117717422.1 Fic family protein -
BL1660_RS04725 1041363..1041661 + 299 Protein_917 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-56)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11889.70 Da        Isoelectric Point: 5.0771

>T177366 WP_071474571.1 NZ_CP062952:1036361-1036684 [Bifidobacterium longum subsp. infantis]
MKRGEIWTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVVDDAAMTNIGRQLMRVLGLL

Download         Length: 324 bp

>T177366 NZ_CP083473:489423-489764 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9339.43 Da        Isoelectric Point: 4.5881

>AT177366 WP_003829112.1 NZ_CP062952:1036129-1036374 [Bifidobacterium longum subsp. infantis]
MSMQIATRVDDEQAALFKETTRQLGTTPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDET
R

Download         Length: 246 bp

>AT177366 NZ_CP083473:489193-489423 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L9TZR4

Antitoxin

Source ID Structure
AlphaFold DB A0A087B6Q6

References