Detailed information of TA system TA177365

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 841182..841790
• Replicon: chromosome
• Accession: NZ_CP062952
• Organism: Bifidobacterium longum subsp. infantis strain JCM 11660

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3BGL7
• Locus tag: BL1660_RS03795
• Protein ID: WP_007056255.1
• Coordinates: 841455..841790 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3BGP0
• Locus tag: BL1660_RS03790
• Protein ID: WP_007056990.1
• Coordinates: 841182..841451 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BL1660_RS03760	836554..837069	+	516	WP_032685213.1	hypothetical protein	-
BL1660_RS03765	837066..837359	+	294	Protein_726	hypothetical protein	-
BL1660_RS03770	837440..838546	+	1107	WP_193641052.1	IS30 family transposase	-
BL1660_RS03775	838552..839154	+	603	Protein_728	hypothetical protein	-
BL1660_RS03780	839151..839831	+	681	WP_003829413.1	ABC transporter ATP-binding protein	-
BL1660_RS03785	839828..840997	+	1170	WP_007056274.1	ABC transporter permease	-
BL1660_RS03790	841182..841451	+	270	WP_007056990.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BL1660_RS03795	841455..841790	+	336	WP_007056255.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BL1660_RS03800	841807..842091	+	285	WP_007056282.1	hypothetical protein	-
BL1660_RS03805	842294..842878	-	585	WP_007056278.1	Fic family protein	-
BL1660_RS03810	842875..843054	-	180	WP_007056286.1	antitoxin VbhA family protein	-
BL1660_RS03815	843268..843909	+	642	WP_007056262.1	hypothetical protein	-
BL1660_RS03820	844002..844295	+	294	WP_012471870.1	hypothetical protein	-
BL1660_RS03825	844945..845268	-	324	WP_012471871.1	amidohydrolase	-
BL1660_RS03830	845297..845917	-	621	WP_007054239.1	NUDIX hydrolase	-
BL1660_RS03835	846019..846693	-	675	WP_077322431.1	YidC/Oxa1 family membrane protein insertase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	824361..861556	37195

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-87)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12650.60 Da
• Isoelectric Point: 9.1088

>T177365 WP_007056255.1 NZ_CP062952:841455-841790 [Bifidobacterium longum subsp. infantis]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELFGQIAGLHPALNQPTAI

Nucleotide

• Length: 336 bp

>T177365 NZ_CP083473:195967-196233 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9844.16 Da
• Isoelectric Point: 4.5742

>AT177365 WP_007056990.1 NZ_CP062952:841182-841451 [Bifidobacterium longum subsp. infantis]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVREKRIPLNLSYTIVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI

Nucleotide

• Length: 270 bp

>AT177365 NZ_CP083473:195704-195967 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Structures

Toxin

• AlphaFold DB: I3BGL7

Antitoxin

• AlphaFold DB: I3BGP0