Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 649621..650501 Replicon chromosome
Accession NZ_CP062952
Organism Bifidobacterium longum subsp. infantis strain JCM 11660

Toxin (Protein)


Gene name relE Uniprot ID F8APN2
Locus tag BL1660_RS02905 Protein ID WP_007052625.1
Coordinates 650010..650501 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4R0V8T5
Locus tag BL1660_RS02900 Protein ID WP_013410773.1
Coordinates 649621..650013 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL1660_RS02895 646777..649476 + 2700 WP_010080853.1 aconitate hydratase AcnA -
BL1660_RS02900 649621..650013 + 393 WP_013410773.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BL1660_RS02905 650010..650501 + 492 WP_007052625.1 type II toxin-antitoxin system VapC family toxin Toxin
BL1660_RS02910 650551..652656 - 2106 WP_007052626.1 DUF262 domain-containing protein -
BL1660_RS02915 652746..653387 - 642 WP_193641176.1 GNAT family N-acetyltransferase -
BL1660_RS02920 653427..654152 - 726 WP_032738970.1 response regulator transcription factor -
BL1660_RS02925 654187..655419 - 1233 WP_193641221.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 536132..685217 149085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18531.70 Da        Isoelectric Point: 6.2348

>T177364 WP_007052625.1 NZ_CP062952:650010-650501 [Bifidobacterium longum subsp. infantis]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDVFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECELAQSLRHAHNDFEDDLIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Download         Length: 492 bp

>T177364 NZ_CP083462:103044-104351 [Aeromonas veronii]
ATGCAGACGCTAACAGTGGCGATGAATGGTGAGGTCGTAGGCACACTGTACCGAGATAACAAAGGGGCCATGTCATTTCA
GTATGCCCCGGAGTGGATCTCGGAACCAGGTTCACGCGCTATTTCCATGTCACTGCCTTTGGGTCATGGCAGGATCACAG
GAAGTGAAGTTTTCAATTTCTTTAGCAACCTCCTACCTGACTCAGAGGCAATTATTGCCAGGATGCAGGCCCGGTTCAGA
GTTGAGACAACACATCCATTTGATTTGCTGGCGAGTGTTGGCCGGGACTGTGTTGGAGCTATCCAGCTCTATTCCCCTGA
TGCGGACATCCCAACTGTAATGGAGACGCTTGCAGAGCCTCTGGATGAAGCTCAGATTGAGCAACTGCTTGAAGGCTACC
AGGAAGCTCCCCTTGGGATGGCTGAGGATGCTGATTTTCGGATCTCGATTGCCGGAGCCCAAGAGAAAACTGCACTGCTT
TGGTATCAGGATCGCTGGCAACGCCCCCTGGGGAGCACCCCAACAAGCCATATTTTTAAGCTACCCATTGGTAAGATTGT
TCAAAATAACATCGATCTCAGTGAGAGTTGCGAGAATGAATGGCTCTGTTTGCGCATTGCAAAGGCCTTCGGTTTTGACG
TCGCCAATGCGGACCTAGCAACGTTCGGCAAGAAGAAGGTGCTTGTAGTTCAGCGTTTTGACCGGCGCTGGTCTAAATCC
GGCGAATGGCTTCTGCGATTGCCCCAAGAAGACTTCTGCCAAGCTCTTGGGATCGCTCCTGCGCTCAAATACGAATCACA
TGGAGGGCCAGGTATTGCTGACGCAATGAAGTTGTTGTTGGGGTCCAGATTTGCGGCCAAGGATAGAGAGCAATTTTTCA
AGTCGCAGATCCTATTCTGGATGTTGGCCGCGATTGATGGGCACGGGAAGAACTTCTCCATTTTCATTGAGCCTGCATCG
TCATTTAGGATGACACCCCTCTACGATGTCATGTCTGCTTTTCCTATCTTCAAAAGCGGGGGAATTGCTGCTCAAAAGGC
AAAGATGGGGATGGCGCTCCAAGGCAAAAACCGCCAATACCGTTTTGCGATGATCCAGCCTCGTCATTTTATCAGTACCG
CCGCCCATGTCGGGTTCCCACCAGATACCGCAGCTCAACTCATGCTCGACATGGCTACCAAGACAGAGGAGGTGGTTGCC
ACAGTCGCGGCTGAGCTGCCAGCCGGTTTCCCAGAGCACATCAGTAGTGCCATCTTCGAGGGGCTGTCCAGCCAGGCGGC
TAAGATCTTGAAGGGAGTAGCCAAATGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15205.33 Da        Isoelectric Point: 5.4043

>AT177364 WP_013410773.1 NZ_CP062952:649621-650013 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDEIADERLKEYRHQSDYARYLEKERSLS

Download         Length: 393 bp

>AT177364 NZ_CP083462:102783-103034 [Aeromonas veronii]
ATGAAAGTGACATCTCCATCCTTACTTGCGGCTGCGGTGCGCGACCAACGCAAGCTCAGCAAACTAACGCAGTCAGAGGC
GGCGAAACAGGTCGGAATCAAGCAGACGACCGTCTCTGATTTTGAACTACGGCCAGAATCTACCAAGCTGGAGACGCTAT
TCAAGCTCCTTGCTGCACTGGATCTGGAGCTTCATGTCGTGAAGCGGGGTTCAACATTGGACGATAATAAAGTCTGGGAT
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8APN2

Antitoxin

Source ID Structure
AlphaFold DB A0A4R0V8T5

References