Detailed information of TA system TA177363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2408545..2409034
• Replicon: chromosome
• Accession: NZ_CP062951
• Organism: Bifidobacterium longum subsp. infantis strain JCM 11347

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: BL1347_RS10810
• Protein ID: WP_032744821.1
• Coordinates: 2408545..2408814 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A4V2N072
• Locus tag: BL1347_RS10815
• Protein ID: WP_032744823.1
• Coordinates: 2408798..2409034 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BL1347_RS10795	2405880..2406602	-	723	WP_193641593.1	hypothetical protein	-
BL1347_RS10800	2406667..2407623	-	957	WP_193641594.1	A/G-specific adenine glycosylase	-
BL1347_RS10805	2407644..2408306	+	663	WP_193641595.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
BL1347_RS10810	2408545..2408814	-	270	WP_032744821.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BL1347_RS10815	2408798..2409034	-	237	WP_032744823.1	ribbon-helix-helix domain-containing protein	Antitoxin
BL1347_RS10820	2409617..2410330	-	714	WP_193641596.1	4'-phosphopantetheinyl transferase superfamily protein	-
BL1347_RS10825	2410341..2411558	-	1218	WP_193642284.1	MFS transporter	-
BL1347_RS10830	2411693..2412880	-	1188	WP_131268326.1	carboxylate--amine ligase	-
BL1347_RS10835	2413139..2413363	-	225	Protein_2105	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10324.17 Da
• Isoelectric Point: 10.3382

>T177363 WP_032744821.1 NZ_CP062951:c2408814-2408545 [Bifidobacterium longum subsp. infantis]
MAWRIEIDKGVQRSMKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVA
HRSKVYKRC

Nucleotide

• Length: 270 bp

>T177363 NZ_CP083457:355301-355651 [Deinococcus taeanensis]
ATGCAGCGCGGTGACATCTATATCGCCGACCTCGACCCCGCGCGCGCCAGCGAAGCAAACAAACGCCGCCCCGTGGTCAT
CGTCAGCGCCAACAGCCTGAACCGCACCGTCCACCGCCTCGGGGCCGGTGCCATCACCGTCGTGCCATTGACCTCCAACG
TCACCCGGGTGTACGACTTCCAGGTCCTGCTGCCCGCTGAACAGACCGGCCTGGATCAGGACAGCAAGGCTCAAGCCGAG
CAGATCCGGACCATCAGTTTCAGTCGCCTGGGGCCAGCGCCCGTCGGAGCCGTTCCAGCGGCCCTGATGGGACAGCTTGA
CGCGGCACTGCGGTTGCACCTGTCGCTGTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8928.15 Da
• Isoelectric Point: 4.2821

>AT177363 WP_032744823.1 NZ_CP062951:c2409034-2408798 [Bifidobacterium longum subsp. infantis]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLGLED

Nucleotide

• Length: 237 bp

>AT177363 NZ_CP083457:355069-355314 [Deinococcus taeanensis]
ATGACTGTTGGGAAGATGAGTGTAAGTCTTGATGCTTCACTCCTGGAGTTCATGGCGCACTACCAGGAGACCCACCAGCT
GCGCTCCCGTTCGGAAGTGGTGGCTCAGGCCTTGACCCTTCTGCGGGACCAGGAACTGGAAGCCCAGTACGCCGCCGCCC
TGAGTGAGTGGCAGGACAGCAGCGACGCCGACCTCTGGGAGCACACCGCCGCCGACGGCCTGGACGGAACCGATGCAGCG
CGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A4V2N072