Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 1922810..1923365 Replicon chromosome
Accession NZ_CP062951
Organism Bifidobacterium longum subsp. infantis strain JCM 11347

Toxin (Protein)


Gene name mazF Uniprot ID S2ZXD7
Locus tag BL1347_RS08640 Protein ID WP_003829109.1
Coordinates 1923042..1923365 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BL1347_RS08635 Protein ID WP_131268479.1
Coordinates 1922810..1923055 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL1347_RS08615 1918220..1918405 - 186 WP_007055507.1 hypothetical protein -
BL1347_RS08620 1918867..1919529 + 663 WP_193642265.1 TetR/AcrR family transcriptional regulator -
BL1347_RS08625 1919686..1920957 + 1272 WP_193641427.1 MFS transporter -
BL1347_RS08630 1921380..1922636 - 1257 WP_193641428.1 HipA domain-containing protein -
BL1347_RS08635 1922810..1923055 + 246 WP_131268479.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BL1347_RS08640 1923042..1923365 + 324 WP_003829109.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BL1347_RS08645 1923582..1924196 - 615 WP_082248120.1 cupin domain-containing protein -
BL1347_RS08650 1924303..1924878 - 576 Protein_1678 class I SAM-dependent methyltransferase -
BL1347_RS08655 1925116..1925481 + 366 WP_013140585.1 YccF domain-containing protein -
BL1347_RS08660 1926026..1927291 + 1266 WP_193641429.1 Fic family protein -
BL1347_RS08665 1927761..1928059 + 299 Protein_1681 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-56)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11859.67 Da        Isoelectric Point: 5.0771

>T177362 WP_003829109.1 NZ_CP062951:1923042-1923365 [Bifidobacterium longum subsp. infantis]
MKRGEIWTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVVDDAAMANIGRQLMRVLGLL

Download         Length: 324 bp

>T177362 NZ_CP083454:c797150-796281 [Stenotrophomonas maltophilia]
GTGACCCACTCTCCACCACTCCCCCAGCGCGTTGCTTCCATCCGGCAACGGCTGCTCGATCTCGCTCGCAGCCGAGGCGA
GGACTTTCAGTTCGTGCTGGACCGGTTCGCCGTTGAGCGCCTGCTCTACCGACTCTCCGCTTCCCGATACCGCGACCAGT
TCCTGCTGAAGGGCGCCATGTTGTTTGCAGTGTGGTTCGACGCCCCCCACCGTCCCACGCGGGATGCCGATTTTCTGCGA
TTCGGCTCTGCAGATCCCGACCATCTGCTGCACATCGCACGGTCGCTCTGTGCAATACCGGACGACGACGGCCTATGCTT
CGACCCGGGCAGCATCGCCATCGAGGCCACCCGCGAAGAAGCGGAGTATGAGGGGTTGCGAATCCGCCTGACCGCACATC
TTGGCCGCTCGCGCTGCCACGTACAGTGGGACGTGGGGTTTGGCGATGCGGTGACTCCCCCACCGCCGGAAATCGCCTAC
CCGGTGATGCTGGATGGCTTTCCTCTCCCCTGCCTGCACGTCTATCCGCGCGAGACCGTGTTTGCCGAAAAGCTGGAGGC
CATTGCGGCACTGGGCATCGCAAACAGCAGGATGAAGGACTTCTTCGACTTGCTGGCACTGGTCCGCGAAGACGCCATGG
ATCGTCCACACCTTGTTGCGGCCATTGGCGCGACGTTTGATCGGCGAAGGACCCCGGCGCCGCCCCCCTTGCCCTACGGA
CTGACTCAGTCGTTCGCCGCAGATACCCAGAAGCAGACCCAGTGGCGCGCCTTCCTGCGCAGGAATCGCCTGATCGCGCC
GGATCTCTCTTCGGTGATTGCCGAGATTGCCGACTATCTGGACACCCTCGACACAACCGTACAGTCCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9321.40 Da        Isoelectric Point: 4.5881

>AT177362 WP_131268479.1 NZ_CP062951:1922810-1923055 [Bifidobacterium longum subsp. infantis]
MSIQIATRVDDEQAALFKETTRQLGTTPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDET
R

Download         Length: 246 bp

>AT177362 NZ_CP083454:c797749-797147 [Stenotrophomonas maltophilia]
ATGGGAAACGCCGAGGCCAACGCACGAAAGCTGTTGCGACGCGCAGGCACCCTGCGCGCCCGCGAGCTGGTGACCGCCGG
GATCGCCCGCGCCCAGCTGACCCGACTGGTCGAGGCCGGTGCGCTGATCCGGCTGTCTCGTGGCGTCTACGCGTTGGCGG
AAAGAAACAGTGACGACACCGATGATGGACTGCGGATCATTGCCGAACGCCTGCCGCACCCCCGTCTGTGCCTGTTGAGT
GCCCTGCGCCTGCATGGCCTGACCACCCAGGCGCCATTCGAACGCTGGGTCTCCATCGGCAACAGCGACCGCGTTCCGCG
GATCGATTGGCCGCCCCTCCGAGTGGTCCGCATGTCGGCAAAGACCCTCAACGCGGGGCTGGAAGAGCGTCGCGTAGGCA
AACGTCTCATATACGTCAGCAATGTAGCCAAAACCGTCGTCGATTGCTTCAAGTTCCGCAATCTCGTAGGACTTGATGTC
GCAATTGAAGCCCTGCGTGACGCGCTTCACAGCCGTGCGACCACGCCGGATGCGCTGATGGAGTATGCGCGGATCTGCCG
CGTTGCCAGACTGATGAGACCGTACCTCGATGCCCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A087B6Q7

Antitoxin

Source ID Structure

References