Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1749772..1750338 Replicon chromosome
Accession NZ_CP062951
Organism Bifidobacterium longum subsp. infantis strain JCM 11347

Toxin (Protein)


Gene name relE Uniprot ID A0A0L7BQL3
Locus tag BL1347_RS07800 Protein ID WP_029680114.1
Coordinates 1750045..1750338 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1S2VZL2
Locus tag BL1347_RS07795 Protein ID WP_071477905.1
Coordinates 1749772..1750041 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL1347_RS07765 1744881..1746014 - 1134 WP_159426768.1 IS1249 family transposase -
BL1347_RS07770 1746309..1747586 + 1278 WP_131232883.1 IS256-like element ISBlo8 family transposase -
BL1347_RS07775 1747926..1748066 + 141 WP_007056287.1 hypothetical protein -
BL1347_RS07780 1748468..1748944 - 477 Protein_1505 histidine kinase -
BL1347_RS07785 1748935..1749147 + 213 Protein_1506 hypothetical protein -
BL1347_RS07790 1749142..1749535 + 394 Protein_1507 ABC transporter permease -
BL1347_RS07795 1749772..1750041 + 270 WP_071477905.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BL1347_RS07800 1750045..1750338 + 294 WP_029680114.1 type II toxin-antitoxin system YafQ family toxin Toxin
BL1347_RS07805 1750396..1750856 + 461 Protein_1510 hypothetical protein -
BL1347_RS07810 1750882..1751289 - 408 WP_193642259.1 hypothetical protein -
BL1347_RS07815 1751464..1751665 - 202 Protein_1512 antitoxin VbhA family protein -
BL1347_RS07820 1751879..1752520 + 642 WP_193641355.1 moaA protein -
BL1347_RS07825 1752622..1753944 - 1323 WP_193641356.1 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1744881..1774895 30014
- flank IS/Tn - - 1746285..1747586 1301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-88)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11160.90 Da        Isoelectric Point: 9.7881

>T177360 WP_029680114.1 NZ_CP062951:1750045-1750338 [Bifidobacterium longum subsp. infantis]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T177360 NZ_CP083454:372280-372585 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9888.18 Da        Isoelectric Point: 4.7872

>AT177360 WP_071477905.1 NZ_CP062951:1749772-1750041 [Bifidobacterium longum subsp. infantis]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGRPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT177360 NZ_CP083454:372626-372928 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7BQL3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2VZL2

References