Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 391293..392173 Replicon chromosome
Accession NZ_CP062950
Organism Bifidobacterium longum subsp. longum strain JCM 11341

Toxin (Protein)


Gene name relE Uniprot ID F8APN2
Locus tag BL1341_RS01615 Protein ID WP_007052625.1
Coordinates 391682..392173 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4R0V8T5
Locus tag BL1341_RS01610 Protein ID WP_013410773.1
Coordinates 391293..391685 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL1341_RS01605 388449..391148 + 2700 WP_013410771.1 aconitate hydratase AcnA -
BL1341_RS01610 391293..391685 + 393 WP_013410773.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BL1341_RS01615 391682..392173 + 492 WP_007052625.1 type II toxin-antitoxin system VapC family toxin Toxin
BL1341_RS01620 392234..394339 - 2106 WP_131223584.1 DUF262 domain-containing protein -
BL1341_RS01625 394429..395070 - 642 WP_117650973.1 GNAT family N-acetyltransferase -
BL1341_RS01630 395111..395251 - 141 Protein_320 response regulator transcription factor -
BL1341_RS01635 395420..396319 + 900 WP_007052631.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18531.70 Da        Isoelectric Point: 6.2348

>T177356 WP_007052625.1 NZ_CP062950:391682-392173 [Bifidobacterium longum subsp. longum]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDVFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECELAQSLRHAHNDFEDDLIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Download         Length: 492 bp

>T177356 NZ_CP083451:c837810-837631 [Comamonas odontotermitis]
GTGAAGCAAAGCGAATTCAGACGGTATCTAGCATCGCTAGGCGCTACGTTCCAAGAGGGAGCCAGACACACAAAGGTCTA
CCTCAACGGCAAGCAAACAGTGATGCCAAGACACCCAAGCAGAGAGCTGATGGAAGGCACCAGAAAAGCAATCCTGAAGC
AGTTAGGAATCAACGAATAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15205.33 Da        Isoelectric Point: 5.4043

>AT177356 WP_013410773.1 NZ_CP062950:391293-391685 [Bifidobacterium longum subsp. longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDEIADERLKEYRHQSDYARYLEKERSLS

Download         Length: 393 bp

>AT177356 NZ_CP083451:c837566-837141 [Comamonas odontotermitis]
ATGAAATACCCAGCACTTTTTACTGAAGCGCCAGAGGGTGGCTATACCGTGACATTCCGGGACATTCCCGAAGCAATCAC
CGAGGGCCAGACTCTTGAAGAGGCGCGCGAGATGGCAGCAGATGCATTGCTGACCGCCATGGACTTCTATTTCGAGGACG
GGCGAGCCGTACCCGATCCATCTGCACCCGAAGCCGGGGAGGAGCTTGTTGCCCTCCCCCTTTCGGTATGGGCAAAGGTG
CAACTGCTCAATCTGCGGATCCAGAAGAATGCACGGCCAGCCGACATTGCGCGCGCCATGGGGATCAAGCCCCAGGAGGT
GACGCGCATCCTCGATCTGCACCACGCGACCAAGATTGACACCTTGGCCGCCGCTTTCCATGCCATGGATTCCGAGCTGT
CCATTGCAGTGATTCCAGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8APN2

Antitoxin

Source ID Structure
AlphaFold DB A0A4R0V8T5

References