Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 800919..801799 Replicon chromosome
Accession NZ_CP062947
Organism Bifidobacterium longum subsp. longum strain KCTC 5914

Toxin (Protein)


Gene name relE Uniprot ID F8APN2
Locus tag BL5914_RS03355 Protein ID WP_007052625.1
Coordinates 801308..801799 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4R0V8T5
Locus tag BL5914_RS03350 Protein ID WP_013410773.1
Coordinates 800919..801311 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL5914_RS03345 798075..800774 + 2700 WP_114555089.1 aconitate hydratase AcnA -
BL5914_RS03350 800919..801311 + 393 WP_013410773.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BL5914_RS03355 801308..801799 + 492 WP_007052625.1 type II toxin-antitoxin system VapC family toxin Toxin
BL5914_RS03360 801849..803954 - 2106 WP_007052626.1 DUF262 domain-containing protein -
BL5914_RS03365 804044..804685 - 642 WP_007052627.1 GNAT family N-acetyltransferase -
BL5914_RS03370 804725..805450 - 726 WP_007056206.1 response regulator transcription factor -
BL5914_RS03375 805485..806717 - 1233 WP_007056207.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 728750..824902 96152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18531.70 Da        Isoelectric Point: 6.2348

>T177350 WP_007052625.1 NZ_CP062947:801308-801799 [Bifidobacterium longum subsp. longum]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDVFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECELAQSLRHAHNDFEDDLIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Download         Length: 492 bp

>T177350 NZ_CP083448:c738878-738516 [Pantoea eucrina]
ATGAAAATCTTACCTGCAACAACTCAGCGGGCGGCTAAGCCGTGCCCGTCTCCCGTGACGGTCTGGCAGATGCTGCTTAC
CCGTCTGCTGGAACAACATTATGGCCTTACCCTGAATGACACGCCGTTCAGCGATGAAACCGTTATTCAGGAACATATCA
ACGCCGGTATTACGCTGGCTGATGCAGTCAACTTTCTGGTGGATAAGTACGAACTGGTTCGTATCGATCGCAGAGGATTG
AGTTGGCAGGAGCAATCCCCCTATCTTCGGGCTGTAGATATCCTGCGAGCTCGACAGGCAACTGGGTTGTTGCGAGGCGG
CATAATTTTTCGACACGCTGAATCTTGCGTGCAGCTTTCCTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15205.33 Da        Isoelectric Point: 5.4043

>AT177350 WP_013410773.1 NZ_CP062947:800919-801311 [Bifidobacterium longum subsp. longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDEIADERLKEYRHQSDYARYLEKERSLS

Download         Length: 393 bp

>AT177350 NZ_CP083448:c739229-738903 [Pantoea eucrina]
ATGCCATTGACTGATGTAATACAGTGGGGATTACAGCGAAATTTCACACCGAATTTTGGCGCAAGGCTGGTACAGGAAGG
CAACCGACTGCACTACCTGGCTGACCGGGCCAGTATCACCGGTAAATTTGGTGACGCTGAATGTCTGAAGCTGGAAGAAG
CATTCCCGCATTTTATCCGCCAGATGGAACTGATGCTGAGCACTGGCGAACTAAACCCTCGTCATTCCCACTGCGTCACT
TTGTACCACAATGCTTTCACCTGTGAAGCAGATACTCTCGGCAGTTGCGGTTACGTCTACATCGTTATTTATCCCACTCA
ACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8APN2

Antitoxin

Source ID Structure
AlphaFold DB A0A4R0V8T5

References