Detailed information of TA system TA177344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TacT2-ataR/DUF1778(antitoxin)
• Location: 1197553..1198304
• Replicon: chromosome
• Accession: NZ_CP062946
• Organism: Thalassotalea sp. LPB0316

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: LP316_RS05320
• Protein ID: WP_193023092.1
• Coordinates: 1197810..1198304 (+)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: LP316_RS05315
• Protein ID: WP_193023091.1
• Coordinates: 1197553..1197819 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP316_RS05290	1193145..1193939	+	795	WP_193023081.1	hypothetical protein	-
LP316_RS05295	1194011..1194445	-	435	WP_193023083.1	protoporphyrinogen oxidase HemJ	-
LP316_RS05300	1194445..1196175	-	1731	WP_193023085.1	chloride channel protein	-
LP316_RS05305	1196188..1196916	+	729	WP_193023087.1	hypothetical protein	-
LP316_RS05310	1197025..1197366	+	342	WP_193023089.1	iron-sulfur cluster insertion protein ErpA	-
LP316_RS05315	1197553..1197819	+	267	WP_193023091.1	DUF1778 domain-containing protein	Antitoxin
LP316_RS05320	1197810..1198304	+	495	WP_193023092.1	GNAT family N-acetyltransferase	Toxin
LP316_RS05325	1198421..1199047	-	627	WP_193023093.1	hypothetical protein	-
LP316_RS05330	1199133..1199777	-	645	WP_193023094.1	hypothetical protein	-
LP316_RS05335	1199855..1200424	-	570	WP_193023095.1	hypothetical protein	-
LP316_RS05340	1200580..1201227	-	648	WP_193023096.1	hypothetical protein	-
LP316_RS05345	1201773..1202861	+	1089	WP_193023097.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-88)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 17988.84 Da
• Isoelectric Point: 8.6740

>T177344 WP_193023092.1 NZ_CP062946:1197810-1198304 [Thalassotalea sp. LPB0316]
MEITAPHLLEDKHNLRGFCCGKQALDSWLYNNALKNHQRNNSKVYVVTNGNHDVIGYYAVAMGSVQRNSALSSLKRNSPD
PIPMVVLARLAVDQNYKGLGIGAGLLKDCMLRSVQAMDVIGGAGVLVHAIDEEAKQFYKKFGFSESPIDPMVLMARIVDI
KASI

Nucleotide

• Length: 495 bp

>T177344 NZ_CP083445:2954764-2955132 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10013.48 Da
• Isoelectric Point: 5.0790

>AT177344 WP_193023091.1 NZ_CP062946:1197553-1197819 [Thalassotalea sp. LPB0316]
MANKTAPINMRVEPSVRDIIDAAANLMKLDRSVFIQQVVLKEAQKILTNQRDFILDEQAFEAFEQALNNDPVKSDGINDL
LSRKSPWK

Nucleotide

• Length: 267 bp

>AT177344 NZ_CP083445:2954546-2954767 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA