Detailed information of TA system TA177343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 741150..741624
• Replicon: chromosome
• Accession: NZ_CP062946
• Organism: Thalassotalea sp. LPB0316

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LP316_RS03315
• Protein ID: WP_193022674.1
• Coordinates: 741150..741416 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LP316_RS03320
• Protein ID: WP_193022675.1
• Coordinates: 741403..741624 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP316_RS03280	736577..737548	-	972	WP_193022667.1	integron integrase	-
LP316_RS03285	737795..738115	+	321	WP_193022668.1	hypothetical protein	-
LP316_RS03290	738767..739108	+	342	WP_193022669.1	hypothetical protein	-
LP316_RS03295	739217..739534	+	318	WP_193022670.1	hypothetical protein	-
LP316_RS03300	739640..740050	+	411	WP_193022671.1	hypothetical protein	-
LP316_RS03305	740158..740574	+	417	WP_193022672.1	hypothetical protein	-
LP316_RS03310	740691..740999	+	309	WP_193022673.1	hypothetical protein	-
LP316_RS03315	741150..741416	+	267	WP_193022674.1	BrnT family toxin	Toxin
LP316_RS03320	741403..741624	+	222	WP_193022675.1	CopG family transcriptional regulator	Antitoxin
LP316_RS03325	741856..743112	+	1257	WP_193023794.1	DUF1214 domain-containing protein	-
LP316_RS03330	743215..743481	+	267	WP_193022676.1	hypothetical protein	-
LP316_RS03335	744023..745630	-	1608	WP_193022677.1	GMC family oxidoreductase N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	736577..743481	6904

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10309.58 Da
• Isoelectric Point: 5.6334

>T177343 WP_193022674.1 NZ_CP062946:741150-741416 [Thalassotalea sp. LPB0316]
MYTFEYDPKKSEINLDKHGIDFEEAQSLWNDPDLVEIPANTSDEPRSLVIAIHKGKCWSAVITHRTPNVRIISVRRSRKN
EVEFYESF

Nucleotide

• Length: 267 bp

>T177343 NZ_CP083445:c2552569-2552186 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTACCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8509.66 Da
• Isoelectric Point: 5.8433

>AT177343 WP_193022675.1 NZ_CP062946:741403-741624 [Thalassotalea sp. LPB0316]
MKASEFDKKFDDGEDILSNLDLSKAKRTTQETKRVNVDFPTWMLDSLDREASRVGVTRQSIIKVWLAERLEHL

Nucleotide

• Length: 222 bp

>AT177343 NZ_CP083445:c2552811-2552569 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA