Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 614711..616259 Replicon chromosome
Accession NZ_CP062946
Organism Thalassotalea sp. LPB0316

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LP316_RS02760 Protein ID WP_193022566.1
Coordinates 614711..615997 (-) Length 429 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LP316_RS02765 Protein ID WP_193022567.1
Coordinates 615999..616259 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP316_RS02745 610217..610804 + 588 WP_193022563.1 class I SAM-dependent methyltransferase -
LP316_RS02750 610838..613954 + 3117 WP_193022564.1 DEAD/DEAH box helicase family protein -
LP316_RS02755 614036..614641 + 606 WP_193022565.1 DUF1294 domain-containing protein -
LP316_RS02760 614711..615997 - 1287 WP_193022566.1 type II toxin-antitoxin system HipA family toxin Toxin
LP316_RS02765 615999..616259 - 261 WP_193022567.1 helix-turn-helix domain-containing protein Antitoxin
LP316_RS02770 616935..618860 - 1926 WP_193022568.1 prolyl oligopeptidase family serine peptidase -
LP316_RS02775 619019..620530 - 1512 WP_193022569.1 tryptophan 7-halogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 429 a.a.        Molecular weight: 48140.10 Da        Isoelectric Point: 7.2896

>T177342 WP_193022566.1 NZ_CP062946:c615997-614711 [Thalassotalea sp. LPB0316]
MHLNVSLNGIKVGVLSKDKNGGLHFSYTQEWMERSGARPISLSLPITKQKYSGDVVYNFFDNLLPDNLDIRNKIQARFDV
ATGHAFDLLAAIGNDCVGAIQLSTAEPELLNKLSFTPLSELEIEKLLQGYKHTPLGMEIDDEDFRISIAGAQEKTALLNI
DGQWAKPIGTTPTSHIIKLPMGVLPQVGIDLTDSCENEFICLELARAFGFEVANTQVLHFGEQKVLSIERFDRKYSSDRT
WLMRLPQEDFCQAKGISSAKKYQADGGPGIGDCLQLLSASSNTQDRETFFKTQILFWLLAAIDGHGKNFSVFLEPNNKYR
MTPLYDILSAYPMMSKSTLQSQKIKMAMSLKGKNTHFKWSRIQPRHFVSTAAHFKYPVEKAAQHYEYFIDNVEHAITEVE
NKIPANFPEYVATTIFAGLRAQSTKKLR

Download         Length: 1287 bp

>T177342 NZ_CP083445:c2230688-2229771 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9678.92 Da        Isoelectric Point: 9.6905

>AT177342 WP_193022567.1 NZ_CP062946:c616259-615999 [Thalassotalea sp. LPB0316]
MRLNNSKELADYIKLQRKKQGRTQTDVAEHIGLKQKTISGMENSAGSSRIDTLFKIAHELGLSFELTPIGETKSGKSKES
GWDQEW

Download         Length: 261 bp

>AT177342 NZ_CP083445:c2231452-2230694 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTTGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References