Detailed information of TA system TA177341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 285964..286508
• Replicon: chromosome
• Accession: NZ_CP062946
• Organism: Thalassotalea sp. LPB0316

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP316_RS01245
• Protein ID: WP_193022301.1
• Coordinates: 285964..286263 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LP316_RS01250
• Protein ID: WP_193022302.1
• Coordinates: 286251..286508 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP316_RS01230	281261..282088	+	828	WP_193022298.1	hypothetical protein	-
LP316_RS01235	282090..284669	+	2580	WP_193022299.1	[protein-PII] uridylyltransferase	-
LP316_RS01240	284891..285868	+	978	WP_193022300.1	methylenetetrahydrofolate reductase	-
LP316_RS01245	285964..286263	-	300	WP_193022301.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP316_RS01250	286251..286508	-	258	WP_193022302.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LP316_RS01260	288413..289093	+	681	WP_193022303.1	tetratricopeptide repeat protein	-
LP316_RS01265	289213..290298	+	1086	WP_193022304.1	sensor histidine kinase	-
LP316_RS01270	290300..290902	+	603	WP_193022305.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11539.34 Da
• Isoelectric Point: 6.4636

>T177341 WP_193022301.1 NZ_CP062946:c286263-285964 [Thalassotalea sp. LPB0316]
VAEIIWTEPALNNVNDIAEYIALHNEQAAKALVQKVFTKVDRLSEHPNSGKVPAELQGFSFREVVVPPCRIFYKIENDTI
FILYVMRQEQEFRKFMINK

Nucleotide

• Length: 300 bp

>T177341 NZ_CP083445:c2066075-2065791 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9843.46 Da
• Isoelectric Point: 8.5341

>AT177341 WP_193022302.1 NZ_CP062946:c286508-286251 [Thalassotalea sp. LPB0316]
MRVELVTTLKRQATKILAELHESKEPVLITEHGQPSAYLVDVKDYEFMQQRMTILEEIAKGEKAINEGKVFSHSQAKEKM
SKWLK

Nucleotide

• Length: 258 bp

>AT177341 NZ_CP083445:c2066307-2066065 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA