Detailed information of TA system TA177340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 254038..254579
• Replicon: chromosome
• Accession: NZ_CP062946
• Organism: Thalassotalea sp. LPB0316

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LP316_RS01120
• Protein ID: WP_193022278.1
• Coordinates: 254038..254340 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: LP316_RS01125
• Protein ID: WP_193022279.1
• Coordinates: 254340..254579 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP316_RS01100	249474..251939	+	2466	WP_193022276.1	M1 family metallopeptidase	-
LP316_RS01105	251972..252454	+	483	WP_193023775.1	hypothetical protein	-
LP316_RS01110	252905..253114	+	210	WP_193021345.1	hypothetical protein	-
LP316_RS01115	253624..253947	+	324	WP_193022277.1	hypothetical protein	-
LP316_RS01120	254038..254340	-	303	WP_193022278.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP316_RS01125	254340..254579	-	240	WP_193022279.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
LP316_RS01130	254728..254964	+	237	WP_193022280.1	hypothetical protein	-
LP316_RS01135	255082..255273	+	192	WP_193022281.1	hypothetical protein	-
LP316_RS01140	255308..255721	+	414	WP_193022282.1	energy transducer TonB	-
LP316_RS01145	255795..256085	+	291	WP_193022283.1	hypothetical protein	-
LP316_RS01150	256140..256606	-	467	Protein_223	bacterioferritin	-
LP316_RS01155	256618..257082	-	465	WP_193022284.1	bacterioferritin	-
LP316_RS01160	257220..257414	-	195	WP_193022285.1	(2Fe-2S)-binding protein	-
LP316_RS01165	257556..258293	-	738	WP_193022286.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11814.72 Da
• Isoelectric Point: 9.9982

>T177340 WP_193022278.1 NZ_CP062946:c254340-254038 [Thalassotalea sp. LPB0316]
MSRFELSVKAKSDLIKIAKYTQLTWGTKQRNDYLKLLDNAFHQLAEEPMLGTSCDYIREGYRKHPQGSHIIYYKEFRENQ
ILIVRILHKSMDVNRALGKI

Nucleotide

• Length: 303 bp

>T177340 NZ_CP083445:c1958740-1958207 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATAAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8753.62 Da
• Isoelectric Point: 4.2397

>AT177340 WP_193022279.1 NZ_CP062946:c254579-254340 [Thalassotalea sp. LPB0316]
MAKNTSVTLGEHFDQFINQQVSSGRYGSASEVVRAGLRALEDQETQLMILRSMLVEGENSGVADYSYDSLISELDKDNH

Nucleotide

• Length: 240 bp

>AT177340 NZ_CP083445:c1959017-1958751 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA