Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 2203091..2203971 Replicon chromosome
Accession NZ_CP062945
Organism Bifidobacterium longum subsp. longum strain JCM 11340

Toxin (Protein)


Gene name relE Uniprot ID F8APN2
Locus tag BL1134_RS09380 Protein ID WP_007052625.1
Coordinates 2203480..2203971 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4R0V8T5
Locus tag BL1134_RS09375 Protein ID WP_013410773.1
Coordinates 2203091..2203483 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL1134_RS09370 2200247..2202946 + 2700 WP_013410771.1 aconitate hydratase AcnA -
BL1134_RS09375 2203091..2203483 + 393 WP_013410773.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BL1134_RS09380 2203480..2203971 + 492 WP_007052625.1 type II toxin-antitoxin system VapC family toxin Toxin
BL1134_RS09385 2204032..2206137 - 2106 WP_131223584.1 DUF262 domain-containing protein -
BL1134_RS09390 2206227..2206868 - 642 WP_117650973.1 GNAT family N-acetyltransferase -
BL1134_RS09395 2206909..2207049 - 141 Protein_1814 response regulator transcription factor -
BL1134_RS09400 2207218..2208117 + 900 WP_007052631.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18531.70 Da        Isoelectric Point: 6.2348

>T177338 WP_007052625.1 NZ_CP062945:2203480-2203971 [Bifidobacterium longum subsp. longum]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDVFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECELAQSLRHAHNDFEDDLIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Download         Length: 492 bp

>T177338 NZ_CP083444:1886607-1886876 [Bartonella taylorii]
TTGGCTTGGACGATTAGATATGAAAAAAAAGCTCTTAGTTTTTTAAAAAAATGCGATAAAAAAGAAGCACGGAGGATTGT
TGATTTTTTAGATCAACATGTTGCTCCTCTTGAAGATGTGCGTGTAATAGGTAAGCCCTTAAAAGGACAATTATCAGGTT
TATGGAGATATCGTGTAGGAGATTACAGGATACTTTGTGAACTCTATGATAAGGAGCTTGTCGTATTAGTTTTGGCTATT
GGACATAGAAAAAGCATATATAAAGGCTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15205.33 Da        Isoelectric Point: 5.4043

>AT177338 WP_013410773.1 NZ_CP062945:2203091-2203483 [Bifidobacterium longum subsp. longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDEIADERLKEYRHQSDYARYLEKERSLS

Download         Length: 393 bp

>AT177338 NZ_CP083444:1886396-1886623 [Bartonella taylorii]
ATGACGATATCTATTCGATTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTGCGTGAGATTATTGAACGTGGAATAGAGGAAGCAGAGGATTATTATTTAGCTTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8APN2

Antitoxin

Source ID Structure
AlphaFold DB A0A4R0V8T5

References