Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 2167699..2168219 Replicon chromosome
Accession NZ_CP062940
Organism Bifidobacterium longum subsp. longum strain JCM 11343

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1D7UN20
Locus tag BL1343_RS09240 Protein ID WP_032746243.1
Coordinates 2167699..2167953 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID I3B069
Locus tag BL1343_RS09245 Protein ID WP_007051980.1
Coordinates 2167953..2168219 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL1343_RS09215 2163331..2164797 - 1467 WP_193107986.1 ATP-binding protein -
BL1343_RS09220 2165096..2165341 - 246 WP_007053507.1 hypothetical protein -
BL1343_RS09225 2165580..2166128 + 549 WP_193107955.1 hypothetical protein -
BL1343_RS09230 2166139..2166405 + 267 Protein_1779 hypothetical protein -
BL1343_RS09235 2166606..2167595 + 990 WP_131262234.1 hypothetical protein -
BL1343_RS09240 2167699..2167953 - 255 WP_032746243.1 Txe/YoeB family addiction module toxin Toxin
BL1343_RS09245 2167953..2168219 - 267 WP_007051980.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BL1343_RS09250 2168388..2168768 + 381 WP_060868194.1 hypothetical protein -
BL1343_RS09255 2168791..2169156 + 366 WP_050492047.1 hypothetical protein -
BL1343_RS09260 2169533..2170387 - 855 WP_193107992.1 hypothetical protein -
BL1343_RS09265 2170655..2170972 - 318 WP_101026266.1 HigA family addiction module antidote protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2121484..2209428 87944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-76)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9918.37 Da        Isoelectric Point: 8.4862

>T177335 WP_032746243.1 NZ_CP062940:c2167953-2167699 [Bifidobacterium longum subsp. longum]
MLLCWTEDAWADYLYWQSQDRKTLKRVNALIRDMQRTPFEGIGKPEPLKWGLSGAWSRRIDSANRIIYTVADDRLCILSA
KDHY

Download         Length: 255 bp

>T177335 NZ_CP083444:c1030831-1030517 [Bartonella taylorii]
ATGATACGTAAAAGAACGAATAAAGATGATTTGGTGATTGAACCTTTTGCGGATAAGCGTTGTAAAGATCTTTTAGAAGG
TAATCCGCCTAAAGGTTTTCCAACAACTCTAGTGCGTATAGCCCAAAGAAAATTGTTTATGCTCGATAAAGCAGTTGATC
TAAAAGATTTGCGCAGTCTCCCAGGAAATCGTTTAGAAGCATTGAAAGGAGAACGGAAAGGCCAATATTCTATTCGTATT
AATGACCAGTTTCGTGTTTGTTTTGAATGGCGTTCTAATGGCGCCTATGAAGTTGAAATCGTAGATTATCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9922.13 Da        Isoelectric Point: 4.3407

>AT177335 WP_007051980.1 NZ_CP062940:c2168219-2167953 [Bifidobacterium longum subsp. longum]
MTQAVAYSNFRANLKTYMRRVNEDADTLLVTNADPEDNVVVMSADDYDSLMETLRVYQNPYLSDKVMRGMAQVRQGQTMA
HDLVEAGA

Download         Length: 267 bp

>AT177335 NZ_CP083444:c1030500-1030204 [Bartonella taylorii]
ATGAAAAATTATATAGCGATTCATCCCGGAGAAATTTTACGAGAGGAATATTTAAAAGAATATGCTCTCTCTGCTTATGC
TCTTGCAAAAGCATTAAATGTTCCACGCACGAGAATAGAACGTATTGTTGCTGAAAATAGTCCAGTGACTCCCGATACAG
CACTAAGATTAGCCTATTTTTTTGATACTACTGCTGAATTTTGGCTTAACATGCAAGCTGCTTATGACGTTAGTATATTA
CAAACTGAAAAAGCAGACGAATTTGCCAAAATCAATAAATTTGAATGTAGGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7UN20

Antitoxin

Source ID Structure
AlphaFold DB I3B069

References