Detailed information of TA system TA177334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 282086..282939
• Replicon: chromosome
• Accession: NZ_CP062940
• Organism: Bifidobacterium longum subsp. longum strain JCM 11343

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V6XWY1
• Locus tag: BL1343_RS01340
• Protein ID: WP_007054468.1
• Coordinates: 282086..282577 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V6XX41
• Locus tag: BL1343_RS01345
• Protein ID: WP_008783109.1
• Coordinates: 282577..282939 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BL1343_RS01320	277156..278388	+	1233	WP_007056207.1	sensor histidine kinase	-
BL1343_RS01325	278423..279148	+	726	WP_007056206.1	response regulator transcription factor	-
BL1343_RS01330	279188..279829	+	642	WP_007052627.1	GNAT family N-acetyltransferase	-
BL1343_RS01335	279919..282024	+	2106	WP_007052626.1	DUF262 domain-containing protein	-
BL1343_RS01340	282086..282577	-	492	WP_007054468.1	PIN domain-containing protein	Toxin
BL1343_RS01345	282577..282939	-	363	WP_008783109.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BL1343_RS01350	283085..285784	-	2700	WP_131210917.1	aconitate hydratase AcnA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-141)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-53)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18328.91 Da
• Isoelectric Point: 4.5590

>T177334 WP_007054468.1 NZ_CP062940:c282577-282086 [Bifidobacterium longum subsp. longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNITLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Nucleotide

• Length: 492 bp

>T177334 NZ_CP083444:615525-615809 [Bartonella taylorii]
ATGAAAACTACACCATTTAAACCAGAAGAATATCTTGAAACCACTGAGGAACAACAAATATTTCTCAATGAAGCCTTCAA
AACAGGTGATGCTGCTCACATAGCGGATGCCCTTGGTATTGTTGCACGTGCTCAAAATATGAGAGCCTTAGCAAAAGAAA
CCAATCGTGAACGCAGTGGTTTATATCGCTCCTTAAGCAAAACAGGTGACCCTAAACTTTCTACCTTAGTCGCTGTCTTA
TCTGCCCTTAATCTGCAACTCTCTGTACAGTCTTCTACTTCATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13974.03 Da
• Isoelectric Point: 5.0733

>AT177334 WP_008783109.1 NZ_CP062940:c282939-282577 [Bifidobacterium longum subsp. longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Nucleotide

• Length: 363 bp

>AT177334 NZ_CP083444:615236-615544 [Bartonella taylorii]
ATGATAACCATTCATAAAACTACAGAATTTGATACTTGGCTTAAAAAACTCAACGATAAAGGCGTTAAAGCTATTATTCT
TCAACGTGTTATACGATTAAGACAAGGTCTTTTAGGTGATGTTAAATTCTTTAATGGCATTGGTGAATTACGTATCCACT
ATGGGGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGTGGTGGAGATAAATCAACG
CAGAAAAGAGATATTGAACGAGCGTTAAAGTTAAAAGAGGAGTACAGTGATGAAAACTACACCATTTAA

Structures

Toxin

• AlphaFold DB: V6XWY1

Antitoxin

• AlphaFold DB: V6XX41