Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 2497056..2497615 Replicon chromosome
Accession NZ_CP062939
Organism Bifidobacterium subtile strain KCTC 3272

Toxin (Protein)


Gene name relE Uniprot ID A0A087DNH2
Locus tag BS3272_RS10450 Protein ID WP_024464708.1
Coordinates 2497056..2497346 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A087DNH1
Locus tag BS3272_RS10455 Protein ID WP_024464707.1
Coordinates 2497349..2497615 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BS3272_RS10450 2497056..2497346 - 291 WP_024464708.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BS3272_RS10455 2497349..2497615 - 267 WP_024464707.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-87)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11214.68 Da        Isoelectric Point: 8.1222

>T177332 WP_024464708.1 NZ_CP062939:c2497346-2497056 [Bifidobacterium subtile]
MLVPEYTTGFERDVKRMTRKHVNTEGLRRVIRLVLADDEQSREELRRRHRAHRLTGDWSGVLECHIDNSADSLLIWRTAS
GTAVFLRVGSHDELFQ

Download         Length: 291 bp

>T177332 NZ_CP083443:c5393431-5393048 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10154.35 Da        Isoelectric Point: 4.5216

>AT177332 WP_024464707.1 NZ_CP062939:c2497615-2497349 [Bifidobacterium subtile]
MTTVTVRVDDETKLKASNIAEDFGFDLSSVTRAFYRQMVRERRIPLNLSYEPTPNEQTLAAIHEAEEIAQTGRQRFKNAD
EMFDSLEI

Download         Length: 267 bp

>AT177332 NZ_CP083443:c5393673-5393431 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A087DNH2

Antitoxin

Source ID Structure
AlphaFold DB A0A087DNH1

References