Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 1650184..1650719 Replicon chromosome
Accession NZ_CP062939
Organism Bifidobacterium subtile strain KCTC 3272

Toxin (Protein)


Gene name yoeB Uniprot ID A0A087EA04
Locus tag BS3272_RS07100 Protein ID WP_024462786.1
Coordinates 1650184..1650441 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A087EA05
Locus tag BS3272_RS07105 Protein ID WP_033502458.1
Coordinates 1650438..1650719 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BS3272_RS07070 1645849..1646754 - 906 WP_024462791.1 LysR family transcriptional regulator -
BS3272_RS07075 1646986..1647576 + 591 WP_033502460.1 NAD(P)-binding domain-containing protein -
BS3272_RS07080 1648021..1648533 - 513 WP_024462789.1 hypothetical protein -
BS3272_RS07085 1648858..1649172 - 315 WP_081672598.1 Txe/YoeB family addiction module toxin -
BS3272_RS07090 1649159..1649410 - 252 WP_033502459.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
BS3272_RS07095 1649596..1650108 + 513 WP_024462787.1 nucleoside 2-deoxyribosyltransferase -
BS3272_RS07100 1650184..1650441 - 258 WP_024462786.1 Txe/YoeB family addiction module toxin Toxin
BS3272_RS07105 1650438..1650719 - 282 WP_033502458.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BS3272_RS07110 1651475..1652746 + 1272 WP_024462783.1 OFA family MFS transporter -
BS3272_RS07115 1653070..1654440 + 1371 WP_024462782.1 serine hydroxymethyltransferase -
BS3272_RS07120 1655193..1655618 - 426 WP_033502457.1 DUF3052 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-64)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10109.52 Da        Isoelectric Point: 7.8568

>T177331 WP_024462786.1 NZ_CP062939:c1650441-1650184 [Bifidobacterium subtile]
MIIAWTQDAWDDYLFWQSQDRKTLKRINRLINDMCNHPFEGIGKPEALRWGLQGAWSRRIDSANRIVYTVVEGRLCIISA
RDHYE

Download         Length: 258 bp

>T177331 NZ_CP083443:c5080857-5079940 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCATCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10542.74 Da        Isoelectric Point: 4.5718

>AT177331 WP_033502458.1 NZ_CP062939:c1650719-1650438 [Bifidobacterium subtile]
MVQAVAYSNFRKDLKSYMRKVNEDSDMLLVTNTNPDDDVVVMSAADYDSMMETLRVYQNPYLRNKITHGLEQVHQGRVQE
HALFDDDGSGAAA

Download         Length: 282 bp

>AT177331 NZ_CP083443:c5081621-5080863 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A087EA04

Antitoxin

Source ID Structure
AlphaFold DB A0A087EA05

References