Detailed information of TA system TA177330

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-yefM/YoeB-RelB
• Location: 1648858..1649410
• Replicon: chromosome
• Accession: NZ_CP062939
• Organism: Bifidobacterium subtile strain KCTC 3272

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: -
• Locus tag: BS3272_RS07085
• Protein ID: WP_081672598.1
• Coordinates: 1648858..1649172 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A087EA02
• Locus tag: BS3272_RS07090
• Protein ID: WP_033502459.1
• Coordinates: 1649159..1649410 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BS3272_RS07060	1644025..1645071	-	1047	WP_024462792.1	anthranilate phosphoribosyltransferase	-
BS3272_RS07070	1645849..1646754	-	906	WP_024462791.1	LysR family transcriptional regulator	-
BS3272_RS07075	1646986..1647576	+	591	WP_033502460.1	NAD(P)-binding domain-containing protein	-
BS3272_RS07080	1648021..1648533	-	513	WP_024462789.1	hypothetical protein	-
BS3272_RS07085	1648858..1649172	-	315	WP_081672598.1	Txe/YoeB family addiction module toxin	Toxin
BS3272_RS07090	1649159..1649410	-	252	WP_033502459.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BS3272_RS07095	1649596..1650108	+	513	WP_024462787.1	nucleoside 2-deoxyribosyltransferase	-
BS3272_RS07100	1650184..1650441	-	258	WP_024462786.1	Txe/YoeB family addiction module toxin	-
BS3272_RS07105	1650438..1650719	-	282	WP_033502458.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
BS3272_RS07110	1651475..1652746	+	1272	WP_024462783.1	OFA family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (29-104)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12412.11 Da
• Isoelectric Point: 10.1329

>T177330 WP_081672598.1 NZ_CP062939:c1649172-1648858 [Bifidobacterium subtile]
MTSSRPLPVIVIGQVRYQLTRHVLWASGVHDDYLEWRRTDAKRFERIQRLIVDIDQHPFSGLGKPEPLRHNLAGAWSRHV
RQEHRLIYHVDNQGIHLYSVRDHY

Nucleotide

• Length: 315 bp

>T177330 NZ_CP083443:c4924528-4924244 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9689.81 Da
• Isoelectric Point: 4.2790

>AT177330 WP_033502459.1 NZ_CP062939:c1649410-1649159 [Bifidobacterium subtile]
MLTLPYTSFRNNMKENMRRLHDDADVMLVTNRDPADNIVVMSQDDYESLMETLRVQSNPDLHRRVLAGMRQSAEGAEEEY
DEL

Nucleotide

• Length: 252 bp

>AT177330 NZ_CP083443:c4924760-4924518 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A087EA02