Detailed information of TA system TA177328

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 130665..131538
• Replicon: chromosome
• Accession: NZ_CP062938
• Organism: Bifidobacterium eulemuris strain DSM 100216

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: BE0216_RS00605
• Protein ID: WP_143249274.1
• Coordinates: 131212..131538 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: BE0216_RS00600
• Protein ID: WP_094636378.1
• Coordinates: 130665..131222 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE0216_RS00570	127533..127799	+	267	WP_094636383.1	Abi family protein	-
BE0216_RS00575	127812..128159	+	348	WP_094636382.1	Abi family protein	-
BE0216_RS00580	128163..128519	-	357	WP_094636381.1	type II toxin-antitoxin system PemK/MazF family toxin	-
BE0216_RS00585	128506..128793	-	288	WP_094636380.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
BE0216_RS00590	129051..129848	+	798	WP_094636469.1	DUF1295 domain-containing protein	-
BE0216_RS00595	130003..130332	+	330	WP_094636379.1	DUF2316 family protein	-
BE0216_RS00600	130665..131222	+	558	WP_094636378.1	DUF4065 domain-containing protein	Antitoxin
BE0216_RS00605	131212..131538	+	327	WP_143249274.1	hypothetical protein	Toxin
BE0216_RS00610	131569..131916	+	348	WP_169714249.1	MGMT family protein	-
BE0216_RS00615	132081..132623	-	543	WP_094636376.1	thioredoxin-dependent thiol peroxidase	-
BE0216_RS00620	132792..134147	-	1356	WP_094636375.1	amidohydrolase family protein	-
BE0216_RS00625	134300..134785	+	486	WP_094636374.1	D-tyrosyl-tRNA(Tyr) deacylase	-
BE0216_RS00630	134891..135505	+	615	WP_094636373.1	ATP-dependent Clp protease proteolytic subunit	-
BE0216_RS00635	135509..136210	+	702	WP_094636372.1	ATP-dependent Clp protease proteolytic subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	116822..136210	19388

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (30-125)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13030.97 Da
• Isoelectric Point: 9.5001

>T177328 WP_143249274.1 NZ_CP062938:131212-131538 [Bifidobacterium eulemuris]
MMTDVRPWQVRRVWFPYREDPSRGKNRRVVVKEVTDDNCVVIYVTSKIEKSHFPDFMLLKDWNEEGFDRASAVRWNRLLK
VPISAFGEHLGDLSPYDRLELQMRYQLR

Nucleotide

• Length: 327 bp

>T177328 NZ_CP083443:4178950-4179168 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 21130.72 Da
• Isoelectric Point: 4.3359

>AT177328 WP_094636378.1 NZ_CP062938:130665-131222 [Bifidobacterium eulemuris]
MDVMDVADFFIATANEGNPEEDDGMTNMKLNKLLFFAQAASLQRFGKPLFDAPLEARKYGPVVKDVYRTFSGYQRDAIAK
VARPFDWKTLDPEVLQLLCDVYRTYARDYSAIGLMRMTHKPGTPWSQAYEEHKNNVISCESIREWVNQTPLMIDETSVSD
SLVTVAELDQHGHPFLPEGWEDDDD

Nucleotide

• Length: 558 bp

>AT177328 NZ_CP083443:4178549-4178923 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG