Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/DinJ(antitoxin)
Location 128163..128793 Replicon chromosome
Accession NZ_CP062938
Organism Bifidobacterium eulemuris strain DSM 100216

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BE0216_RS00580 Protein ID WP_094636381.1
Coordinates 128163..128519 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BE0216_RS00585 Protein ID WP_094636380.1
Coordinates 128506..128793 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE0216_RS00560 123430..124749 + 1320 WP_094636385.1 ATP-binding protein -
BE0216_RS00565 124957..127338 + 2382 WP_158217183.1 DUF2075 domain-containing protein -
BE0216_RS00570 127533..127799 + 267 WP_094636383.1 Abi family protein -
BE0216_RS00575 127812..128159 + 348 WP_094636382.1 Abi family protein -
BE0216_RS00580 128163..128519 - 357 WP_094636381.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BE0216_RS00585 128506..128793 - 288 WP_094636380.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BE0216_RS00590 129051..129848 + 798 WP_094636469.1 DUF1295 domain-containing protein -
BE0216_RS00595 130003..130332 + 330 WP_094636379.1 DUF2316 family protein -
BE0216_RS00600 130665..131222 + 558 WP_094636378.1 DUF4065 domain-containing protein -
BE0216_RS00605 131212..131538 + 327 WP_143249274.1 hypothetical protein -
BE0216_RS00610 131569..131916 + 348 WP_169714249.1 MGMT family protein -
BE0216_RS00615 132081..132623 - 543 WP_094636376.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 116822..136210 19388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-50)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13585.57 Da        Isoelectric Point: 6.3215

>T177327 WP_094636381.1 NZ_CP062938:c128519-128163 [Bifidobacterium eulemuris]
MTMTEPKQFDIWWVPFAFPDKPGKFKNRPSVILEWNDGTRVALVTKVTGNTWRDEPGYVVLRDWQEAGLSKPSAVRCSQL
LRIPRDVFLDDGPVGRLSSYDTDRVVWAINELYPGLFL

Download         Length: 357 bp

>T177327 NZ_CP083443:c4053135-4052818 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10497.92 Da        Isoelectric Point: 4.2666

>AT177327 WP_094636380.1 NZ_CP062938:c128793-128506 [Bifidobacterium eulemuris]
MAKVIVNVDDAVKVEASRLYESMGLNLSTAVNMFLRQSIVDNGLPFTPKAAQRPFTRDTDGYPIVKFNMDDPRIVTPKVV
NGGVVLPEGWDDDDD

Download         Length: 288 bp

>AT177327 NZ_CP083443:c4052825-4052538 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References