Detailed information of TA system TA177323

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3282363..3283004
• Replicon: chromosome
• Accession: NZ_CP062919
• Organism: Acinetobacter baumannii strain Res13-Abat-PEA21-P4-01-A

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2S4T466
• Locus tag: IMO23_RS15860
• Protein ID: WP_000607071.1
• Coordinates: 3282363..3282752 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: IMO23_RS15865
• Protein ID: WP_171059649.1
• Coordinates: 3282759..3283004 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMO23_RS15840	3278067..3278999	+	933	WP_001043692.1	IS5-like element ISAba13 family transposase	-
IMO23_RS15845	3279053..3279676	-	624	Protein_3086	hypothetical protein	-
IMO23_RS15850	3279864..3280430	-	567	WP_000651536.1	rhombosortase	-
IMO23_RS15855	3280508..3281593	-	1086	WP_000049106.1	hypothetical protein	-
IMO23_RS15860	3282363..3282752	-	390	WP_000607071.1	membrane protein	Toxin
IMO23_RS15865	3282759..3283004	-	246	WP_171059649.1	succinate dehydrogenase assembly factor 2	Antitoxin
IMO23_RS15870	3283204..3284376	+	1173	WP_001190557.1	acyl-CoA dehydrogenase family protein	-
IMO23_RS15875	3284423..3285913	-	1491	WP_005134653.1	NAD(P)/FAD-dependent oxidoreductase	-
IMO23_RS15880	3286095..3286472	-	378	WP_001216380.1	50S ribosomal protein L17	-
IMO23_RS15885	3286491..3287498	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3278067..3278999	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15649.98 Da
• Isoelectric Point: 10.4623

>T177323 WP_000607071.1 NZ_CP062919:c3282752-3282363 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T177323 NZ_CP083443:c931476-931093 [Klebsiella pneumoniae]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9856.29 Da
• Isoelectric Point: 4.9108

>AT177323 WP_171059649.1 NZ_CP062919:c3283004-3282759 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKAEPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT177323 NZ_CP083443:c931934-931566 [Klebsiella pneumoniae]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: A0A2S4T466