Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3171161..3171686 Replicon chromosome
Accession NZ_CP062919
Organism Acinetobacter baumannii strain Res13-Abat-PEA21-P4-01-A

Toxin (Protein)


Gene name relE Uniprot ID R9B9L0
Locus tag IMO23_RS15280 Protein ID WP_005134734.1
Coordinates 3171161..3171448 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3F3MMG8
Locus tag IMO23_RS15285 Protein ID WP_005134732.1
Coordinates 3171438..3171686 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMO23_RS15270 3166505..3169255 - 2751 WP_000990825.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -
IMO23_RS15275 3169324..3170592 - 1269 WP_000194108.1 HAMP domain-containing histidine kinase -
IMO23_RS15280 3171161..3171448 - 288 WP_005134734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMO23_RS15285 3171438..3171686 - 249 WP_005134732.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMO23_RS15290 3171689..3172120 - 432 WP_111034461.1 hypothetical protein -
IMO23_RS15295 3172190..3172804 - 615 WP_111034460.1 recombinase family protein -
IMO23_RS15300 3174321..3174968 + 648 WP_195707623.1 hypothetical protein -
IMO23_RS15305 3175061..3175324 + 264 WP_071209756.1 hypothetical protein -
IMO23_RS15310 3175360..3176658 - 1299 WP_071209757.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3171161..3191179 20018


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11073.89 Da        Isoelectric Point: 10.1961

>T177322 WP_005134734.1 NZ_CP062919:c3171448-3171161 [Acinetobacter baumannii]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPRIPKNKLSGHPNRYKIKLRSIGYRLVYEVIDDEVVVIVIAVGR
RENNAVYDDANSRHS

Download         Length: 288 bp

>T177322 NZ_CP083443:786896-787339 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9262.72 Da        Isoelectric Point: 5.0491

>AT177322 WP_005134732.1 NZ_CP062919:c3171686-3171438 [Acinetobacter baumannii]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYETMMEQLEDLELNKIADTRANQKRVRVNID
DL

Download         Length: 249 bp

>AT177322 NZ_CP083443:786669-786899 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R9B9L0

Antitoxin

Source ID Structure
AlphaFold DB A0A3F3MMG8

References