Detailed information of TA system TA177319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2854290..2855878
• Replicon: chromosome
• Accession: NZ_CP062916
• Organism: Raoultella terrigena strain Res13-Abat-PEB01-P1-04-A

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IMO34_RS13545
• Protein ID: WP_195711542.1
• Coordinates: 2854290..2855609 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IMO34_RS13550
• Protein ID: WP_178995326.1
• Coordinates: 2855609..2855878 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMO34_RS13520	2849812..2851098	+	1287	WP_167692446.1	glycoside hydrolase family 10 protein	-
IMO34_RS13525	2851288..2851860	+	573	WP_115192788.1	peroxiredoxin	-
IMO34_RS13530	2851876..2853108	+	1233	WP_123552387.1	thioredoxin family protein	-
IMO34_RS13535	2853123..2853677	+	555	WP_195711540.1	sigma-70 family RNA polymerase sigma factor	-
IMO34_RS13540	2853664..2854293	+	630	WP_041145487.1	DUF1109 family protein	-
IMO34_RS13545	2854290..2855609	-	1320	WP_195711542.1	type II toxin-antitoxin system HipA family toxin	Toxin
IMO34_RS13550	2855609..2855878	-	270	WP_178995326.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IMO34_RS13555	2856074..2856634	-	561	WP_041147618.1	RNA polymerase sigma factor	-
IMO34_RS13560	2856640..2857065	-	426	WP_115192791.1	hypothetical protein	-
IMO34_RS13565	2857205..2858161	-	957	WP_195709297.1	hypothetical protein	-
IMO34_RS13570	2858272..2859510	-	1239	WP_178995099.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	mgtB	2665918..2921949	256031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-66)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 48624.83 Da
• Isoelectric Point: 6.8435

>T177319 WP_195711542.1 NZ_CP062916:c2855609-2854290 [Raoultella terrigena]
MATLVTWMNNERVGELVKLANGAHQFRYEPRWLQNPRARPLSLSLPLQFGNITSDSVFNYFDNLLPDSPLVRDRIVKRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPEGAALATGALTWEALDDARLDALLTAYRADIPLGMINGQEEFRISVAGAQEKTAL
LKMDDRWCIPTATTPTTHIIKLPIGEIRQPDAVLDLSESVDNEYLCLALARALGFAVPDAEIITTRSIRALAVARFDRRW
AQENTRLLRLPQEDLCQAFGIPSSMKYESDGGPGIASIMAFLLGSSEALKDRADFMKFIVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGAGLHISDLKLSMSLKASKGRKTEIQTIYPRHFLATAKEVGFAQQQMLEILRYFADNLP
RAVETVSASLPEDFSPTVYQAIISHTLRNHARLQSGLAG

Nucleotide

• Length: 1320 bp

>T177319 NZ_CP083442:6287976-6288257 [Pseudomonas chlororaphis]
ATGACCTATGAGCTGGAGTTCTCCGAGAAAGCCTGGAAGGAATGGCAAAAGCTGGGCCCCACGCTGAAAGAGCAATTCAA
GAAGAAGCTGCAGGAACGACTCGTCAACCCCCATGTCCCGGCCGATCGCCTGAGCGGTTTGGGCAATGCCTACAAAATCA
AACTGCGCACGGCTGGATACCGCCTGGTGTATCGGGTGGTGGATGAGGTGTTGGTGGTAACGGTCATTGCCGTGGGCAAG
CGGGAGCGGGGAAGTGTTTATCAGCAAGCCGGGAAACGTTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10167.62 Da
• Isoelectric Point: 8.0441

>AT177319 WP_178995326.1 NZ_CP062916:c2855878-2855609 [Raoultella terrigena]
ITPPTIYSPAQLANHIKLVRQKNQWTQSDLARRIGIKQATISNFENHPDKTTLTTLFKILQSLEMTMVVCEKGAMSGPEQ
QDSQRDLEW

Nucleotide

• Length: 270 bp

>AT177319 NZ_CP083442:6287738-6287986 [Pseudomonas chlororaphis]
ATGACCCATGTCCTTCTGTCCAACGTCGTTGCGAGCATTTCCGAGCTAAAGAAAAACCCCATGGGCACCGTTGCGGCCGG
TGGCGGTTCCTCCGTGGCCATCCTCAATCGCAACGAGCCGGCGTTTTACTGCGTTCCGGCCAAGGAATACGAAGCCATGA
TGGAGCGCCTGGAGGATATGGAACTGCTCGCCTTGTGCCGTGAGCGAGAGAATGATCCGACCATCAAGGTTTCGCTCGAT
GACCTATGA