Detailed information of TA system TA177306

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 837433..838090
• Replicon: chromosome
• Accession: NZ_CP062916
• Organism: Raoultella terrigena strain Res13-Abat-PEB01-P1-04-A

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A4V6J1V0
• Locus tag: IMO34_RS04025
• Protein ID: WP_041147144.1
• Coordinates: 837680..838090 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: IMO34_RS04020
• Protein ID: WP_041147145.1
• Coordinates: 837433..837699 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMO34_RS03995	832511..833944	-	1434	WP_041147149.1	6-phospho-beta-glucosidase	-
IMO34_RS04000	834065..834793	-	729	WP_195711560.1	MurR/RpiR family transcriptional regulator	-
IMO34_RS04005	834843..835154	+	312	WP_076948127.1	N(4)-acetylcytidine aminohydrolase	-
IMO34_RS04010	835314..835973	+	660	WP_041147747.1	hemolysin III family protein	-
IMO34_RS04015	836081..837064	-	984	WP_167691177.1	tRNA-modifying protein YgfZ	-
IMO34_RS04020	837433..837699	+	267	WP_041147145.1	FAD assembly factor SdhE	Antitoxin
IMO34_RS04025	837680..838090	+	411	WP_041147144.1	protein YgfX	Toxin
IMO34_RS04030	838139..838660	-	522	WP_041147143.1	flavodoxin FldB	-
IMO34_RS04035	838819..839715	+	897	WP_041147142.1	site-specific tyrosine recombinase XerD	-
IMO34_RS04040	839739..840452	+	714	WP_076948124.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
IMO34_RS04045	840458..842191	+	1734	WP_195710355.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16133.03 Da
• Isoelectric Point: 11.3523

>T177306 WP_041147144.1 NZ_CP062916:837680-838090 [Raoultella terrigena]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACQGEIKLMTDSRLRWQKA
EWEIVGMPWVINSGMLLRLRHPQTRRSQHLWVAADSMDAKEWRDLRRLVLNKPAQD

Nucleotide

• Length: 411 bp

>T177306 NZ_CP083434:2737939-2738091 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10554.07 Da
• Isoelectric Point: 4.8432

>AT177306 WP_041147145.1 NZ_CP062916:837433-837699 [Raoultella terrigena]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKLLFIRLLENDDPDLFNWLMNHGEPSDAQLQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT177306 NZ_CP083434:2737315-2737914 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAGCATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATTGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCATAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A4V6J1V0