177271

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3440481..3441099 Replicon chromosome
Accession NZ_CP062908
Organism Escherichia coli strain Res13-Lact-EB12-05

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag IMP23_RS17730 Protein ID WP_001291435.1
Coordinates 3440881..3441099 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag IMP23_RS17725 Protein ID WP_000344800.1
Coordinates 3440481..3440855 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP23_RS17715 3435570..3436763 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IMP23_RS17720 3436786..3439935 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
IMP23_RS17725 3440481..3440855 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
IMP23_RS17730 3440881..3441099 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
IMP23_RS17735 3441271..3441822 + 552 WP_000102564.1 maltose O-acetyltransferase -
IMP23_RS17740 3441938..3442408 + 471 WP_000136192.1 YlaC family protein -
IMP23_RS17745 3442572..3444122 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
IMP23_RS17750 3444164..3444517 - 354 WP_000878140.1 DUF1428 domain-containing protein -
IMP23_RS17760 3444896..3445207 + 312 WP_000409911.1 MGMT family protein -
IMP23_RS17765 3445238..3445810 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T177271 WP_001291435.1 NZ_CP062908:3440881-3441099 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T177271 NZ_CP083410:c246239-245961 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT177271 WP_000344800.1 NZ_CP062908:3440481-3440855 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT177271 NZ_CP083410:c246502-246242 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References