Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2271557..2272083 Replicon chromosome
Accession NZ_CP062908
Organism Escherichia coli strain Res13-Lact-EB12-05

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IMP23_RS12140 Protein ID WP_000323025.1
Coordinates 2271796..2272083 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IMP23_RS12135 Protein ID WP_000534858.1
Coordinates 2271557..2271796 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP23_RS12110 2266891..2267247 + 357 WP_001374839.1 class I SAM-dependent methyltransferase -
IMP23_RS12115 2267858..2268145 + 288 Protein_2134 hypothetical protein -
IMP23_RS12120 2268914..2270255 + 1342 Protein_2135 ISNCY family transposase -
IMP23_RS12125 2270692..2271024 - 333 WP_001317460.1 FlxA-like family protein -
IMP23_RS12130 2271227..2271532 - 306 WP_001326990.1 hypothetical protein -
IMP23_RS12135 2271557..2271796 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IMP23_RS12140 2271796..2272083 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IMP23_RS12145 2272155..2272310 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
IMP23_RS12150 2272527..2272778 + 252 WP_000980994.1 hypothetical protein -
IMP23_RS12155 2272845..2273123 + 279 WP_012304870.1 hypothetical protein -
IMP23_RS12160 2273125..2274174 + 1050 WP_061350716.1 DUF968 domain-containing protein -
IMP23_RS12165 2274188..2274940 + 753 WP_001047135.1 antitermination protein -
IMP23_RS12170 2275218..2275307 - 90 WP_120795389.1 hypothetical protein -
IMP23_RS12175 2275362..2275574 - 213 WP_000087756.1 cold shock-like protein CspF -
IMP23_RS12180 2275875..2276090 + 216 WP_000066484.1 cold shock-like protein CspB -
IMP23_RS12185 2276844..2277059 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2258285..2320435 62150


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T177269 WP_000323025.1 NZ_CP062908:2271796-2272083 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T177269 NZ_CP083403:c4637808-4637437 [Enterobacter bugandensis]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTGATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATCGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATCCTGGCTACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT177269 WP_000534858.1 NZ_CP062908:2271557-2271796 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT177269 NZ_CP083403:c4638053-4637811 [Enterobacter bugandensis]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAACCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGCGAAGCGATTGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References