Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4224267..4224862 Replicon chromosome
Accession NZ_CP062901
Organism Escherichia coli O152:H23 strain Res13-Lact-ER01-35

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag IMP37_RS20205 Protein ID WP_000239579.1
Coordinates 4224267..4224617 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag IMP37_RS20210 Protein ID WP_001223208.1
Coordinates 4224611..4224862 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP37_RS20185 4219713..4220735 - 1023 WP_001296689.1 ABC transporter permease -
IMP37_RS20190 4220749..4222251 - 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
IMP37_RS20195 4222391..4223347 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
IMP37_RS20200 4223657..4224187 + 531 WP_000055075.1 inorganic diphosphatase -
IMP37_RS20205 4224267..4224617 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
IMP37_RS20210 4224611..4224862 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
IMP37_RS20215 4225074..4225415 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
IMP37_RS20220 4225418..4229197 - 3780 WP_053264521.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T177240 WP_000239579.1 NZ_CP062901:c4224617-4224267 [Escherichia coli O152:H23]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T177240 NZ_CP083366:c2832036-2831857 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCCGACGCTGGCTGAGGGCACAAGGTGTGACCTTCGAAGCCGGCAAGGGCAGTCACTTCAAGGT
GACCGCCCCGAACGGTAAGACAACGACCTTCGCAGATCACGGCGCCAAAGAAATGCCGGAGCCGACACGCAAGGCGATCA
TCAAGCAACTGGGGCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT177240 WP_001223208.1 NZ_CP062901:c4224862-4224611 [Escherichia coli O152:H23]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT177240 NZ_CP083366:c2831816-2831385 [Pseudomonas aeruginosa]
ATGTACAACTTCGCAATCCGTTTCGAGCAAGACGACAGCGCTCCTGGCGTTGCCGTTTTCTGTCGAGACCTTCCAGAGCT
GAACAGCTACGGAAACACCGTCGAGCACGCACTCGGCGAGGCCGTTGATGCCATCGAAACCACATTGTCGCTCTACGTTG
ATCAGCGCCGACCAATTCCAGCGGCTAGCGCTCCAGAACCAGAAGAGCACGTAGTGCATCTTCCAGCGGTGACCGTCGCG
AAGATCGCTCTATGGAACGAGATGATGCGGCGCGACATGCGGAAGGCTGATCTATGCCGGGCTCTAGGCGTCGCCCAAGT
ACAGGTCGACCGCCTCGTCGACTTTCTGCATACCTCGAAGATGGAGCAGTTGGAGTCCGCGTTAGGGGTCTTAGGCTTGC
GTCTTTTCGTGAGTGTGCAGCAGGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References