Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2264253..2264779 | Replicon | chromosome |
| Accession | NZ_CP062901 | ||
| Organism | Escherichia coli O152:H23 strain Res13-Lact-ER01-35 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | IMP37_RS10900 | Protein ID | WP_000323025.1 |
| Coordinates | 2264492..2264779 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | IMP37_RS10895 | Protein ID | WP_000534858.1 |
| Coordinates | 2264253..2264492 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IMP37_RS10860 | 2259439..2259666 | + | 228 | WP_000476993.1 | transcriptional regulator | - |
| IMP37_RS10865 | 2259650..2260171 | + | 522 | WP_000705349.1 | hypothetical protein | - |
| IMP37_RS10870 | 2260152..2261117 | + | 966 | WP_000054504.1 | hypothetical protein | - |
| IMP37_RS10875 | 2261158..2261577 | + | 420 | WP_001151196.1 | DUF977 family protein | - |
| IMP37_RS10880 | 2261611..2262951 | + | 1341 | WP_192958112.1 | ISNCY family transposase | - |
| IMP37_RS10885 | 2263388..2263720 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| IMP37_RS10890 | 2263923..2264228 | - | 306 | WP_071527819.1 | hypothetical protein | - |
| IMP37_RS10895 | 2264253..2264492 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| IMP37_RS10900 | 2264492..2264779 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| IMP37_RS10905 | 2264851..2265006 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| IMP37_RS10910 | 2265223..2265474 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| IMP37_RS10915 | 2265541..2265819 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| IMP37_RS10920 | 2265821..2266870 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| IMP37_RS10925 | 2266884..2267636 | + | 753 | WP_001047135.1 | antitermination protein | - |
| IMP37_RS10930 | 2267914..2268003 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| IMP37_RS10935 | 2268058..2268270 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| IMP37_RS10940 | 2268571..2268786 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| IMP37_RS10945 | 2269540..2269755 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2248926..2300222 | 51296 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T177236 WP_000323025.1 NZ_CP062901:2264492-2264779 [Escherichia coli O152:H23]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T177236 NZ_CP083363:c82432-82091 [Vibrio parahaemolyticus]
ATGACATATGCAGTACCAGAGAAAGGCGATGTAGTAGTAATGAGTTTTAATCCGCAAAGCGGACACGAACAAGCGGGAGA
CAGTCGGCCTGGGCTGGTCATTTCCCCGAAAGAGTTTAACCAAGCAACTGGCTTTGCTCTGGTATGCCCCATAACCAACC
AGTCAAAAGGGTATCCGTTTGAAGTTGAAATAACCGGAAGCCAAAAAACAACGGGTGTGGTGCTGGCTGACCAAGTGAAG
TCCTTGGATTGGCGCGCGCGTCGCGCTCGTGTGGTGGACTCCGTTTCAAACGAAACACTGGGGACTGTGCGGGATTATGT
CACAGCGATTGCTAATGGCTGA
ATGACATATGCAGTACCAGAGAAAGGCGATGTAGTAGTAATGAGTTTTAATCCGCAAAGCGGACACGAACAAGCGGGAGA
CAGTCGGCCTGGGCTGGTCATTTCCCCGAAAGAGTTTAACCAAGCAACTGGCTTTGCTCTGGTATGCCCCATAACCAACC
AGTCAAAAGGGTATCCGTTTGAAGTTGAAATAACCGGAAGCCAAAAAACAACGGGTGTGGTGCTGGCTGACCAAGTGAAG
TCCTTGGATTGGCGCGCGCGTCGCGCTCGTGTGGTGGACTCCGTTTCAAACGAAACACTGGGGACTGTGCGGGATTATGT
CACAGCGATTGCTAATGGCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT177236 WP_000534858.1 NZ_CP062901:2264253-2264492 [Escherichia coli O152:H23]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT177236 NZ_CP083363:c82659-82429 [Vibrio parahaemolyticus]
ATGTCACAAACAATAGCTAAGTGGGGCCACAGCGCAGCTGTGCGTATACCTTCTAAGGTATTGAAAAATATGGATATGGC
GGTGGGTGACAAAGTGGAGGTTAAAGTGTTCAATCAACAAATTATCATTGAACCTGCAAAACCAACACTCGCCCAGCTTT
TGAGTCAGATCACTGATGAAAACCGCCATGATGAAGTAATCACCGAAACTATGGGTAATGAATTGTTATGA
ATGTCACAAACAATAGCTAAGTGGGGCCACAGCGCAGCTGTGCGTATACCTTCTAAGGTATTGAAAAATATGGATATGGC
GGTGGGTGACAAAGTGGAGGTTAAAGTGTTCAATCAACAAATTATCATTGAACCTGCAAAACCAACACTCGCCCAGCTTT
TGAGTCAGATCACTGATGAAAACCGCCATGATGAAGTAATCACCGAAACTATGGGTAATGAATTGTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|