Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 69133..69734 Replicon plasmid unnamed1009
Accession NZ_CP062896
Organism Escherichia coli strain Res13-Lact-ER02-39

Toxin (Protein)


Gene name doc Uniprot ID U9Z1Q0
Locus tag IMP38_RS23170 Protein ID WP_001216047.1
Coordinates 69354..69734 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag IMP38_RS23165 Protein ID WP_001190712.1
Coordinates 69133..69354 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP38_RS23130 64408..64596 + 189 WP_000797279.1 hypothetical protein -
IMP38_RS23135 64598..64776 + 179 Protein_69 hypothetical protein -
IMP38_RS23140 65110..66120 + 1011 WP_042198315.1 hypothetical protein -
IMP38_RS23145 66117..66479 + 363 WP_001261543.1 hypothetical protein -
IMP38_RS23150 67555..67911 - 357 WP_001062545.1 hypothetical protein -
IMP38_RS23155 67912..68496 - 585 WP_042198310.1 hypothetical protein -
IMP38_RS23160 68671..69060 + 390 WP_000506730.1 DNA repair protein -
IMP38_RS23165 69133..69354 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMP38_RS23170 69354..69734 + 381 WP_001216047.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IMP38_RS23175 69739..69918 + 180 WP_000113018.1 hypothetical protein -
IMP38_RS23180 69946..70989 + 1044 WP_195686630.1 DUF968 domain-containing protein -
IMP38_RS23185 71078..71530 + 453 WP_001326849.1 late promoter-activating protein -
IMP38_RS23190 71616..72809 + 1194 WP_047649469.1 hypothetical protein -
IMP38_RS23195 72809..74293 + 1485 WP_000124159.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / aac(3)-VIa / ant(3'')-Ia htpB 1..108020 108020


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13574.27 Da        Isoelectric Point: 5.1514

>T177207 WP_001216047.1 NZ_CP062896:69354-69734 [Escherichia coli]
MRHISPEELVALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T177207 NZ_CP083274:c4481531-4481424 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT177207 WP_001190712.1 NZ_CP062896:69133-69354 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT177207 NZ_CP083274:4481578-4481644 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z1Q0

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References